甜三内酯A - C，从罕见放线菌糖丝菌属中分离出的新型苯基取代的10元大环内酯类化合物
Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.
作者信息
Lu Shan, Nishimura Shinichi, Hirai Go, Ito Masashi, Kawahara Teppei, Izumikawa Miho, Sodeoka Mikiko, Shin-ya Kazuo, Tsuchida Toshio, Kakeya Hideaki
机构信息
Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
Chem Commun (Camb). 2015 May 11;51(38):8074-7. doi: 10.1039/c5cc01953b. Epub 2015 Apr 14.
Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.
从一种罕见的放线菌糖丝菌属菌株A1506中发现了三种新的10元大环内酯类化合物，即糖硫内酯A-C（1-3）。10元环中的所有sp(3)碳都具有手性，这是通过广泛的光谱分析和ECD光谱的TDDFT计算确定的。糖硫内酯B（2）对人肿瘤细胞系HeLa和HT1080表现出细胞毒性。
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