Hong Jiaxu, Yu Zhiqiang, Jiang Chunhui, Zhou Xingtao, Liu Zuguo, Sun Xinghuai, Xu Jianjiang
*MPA, MD, PhD †MD ‡MD, PhD School of Life Sciences, Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China (JH, ZL); Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital, School of Shanghai Medicine, Fudan University, Shanghai, China (JH, ZY, CJ, XZ, XS, JX); State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai, China (XS); Key Laboratory of Myopia, National Health and Family Planning Commission, Shanghai, China (XS); and Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts (JH).
Optom Vis Sci. 2015 May;92(5):589-95. doi: 10.1097/OPX.0000000000000575.
To compare the postoperative measurements of intraocular pressure (IOP) using the Corvis ST Tonometer (CST), ocular response analyzer (ORA), and Goldmann applanation tonometry (GAT) in eyes undergoing laser in situ keratomileusis (LASIK), as well as to analyze the relationship between the corneal biomechanical parameters of the CST and the ORA.
Fifty participants who had undergone LASIK to treat myopia in the previous 3 months were enrolled. Postoperative IOP measurements of these participants were obtained using the CST, ORA (corneal-compensated IOP [IOPcc], Goldmann-correlated IOP [IOPg]), and GAT. Device agreement was calculated by Bland-Altman analysis. The metrics of corneal biomechanical properties were recorded using the ORA and the CST. Corneal biomechanical parameters were compared.
The Bland-Altman analysis revealed a significant bias between CST and GAT, between CST and IOPcc, and between CST and IOPg of 3.4, 1.0, and 3.8, mm Hg, respectively, with 95% limits of agreement of -0.7 to 7.5 mm Hg, -2.1 to 4.2 mm Hg, and -0.4 to 8.0 mm Hg. The ORA-derived IOP measurements, CST-derived IOP, and GAT IOP values showed good correlation with each other. The CST IOP and IOPcc were higher than the GAT IOP (all p < 0.05), whereas IOPg did not differ from the GAT IOP readings. Ocular response analyzer-derived corneal biomechanical parameters (corneal hysteresis and the corneal resistance factor) showed significant correlations with CST-derived parameters, including the maximum deformation amplitude at the corneal apex and the time from start until the first applanation.
The CST offers an alternative method for measuring postoperative IOP in LASIK patients, and it appears to obtain higher IOP values than other tonometry techniques. The technique may facilitate the investigation of corneal biomechanical property changes in LASIK-treated eyes.
比较在接受准分子原位角膜磨镶术（LASIK）的眼中，使用Corvis ST眼压计（CST）、眼反应分析仪（ORA）和Goldmann压平眼压计（GAT）测量眼压的术后结果，并分析CST和ORA的角膜生物力学参数之间的关系。
纳入50名在过去3个月内接受LASIK治疗近视的参与者。使用CST、ORA（角膜补偿眼压[IOPcc]、Goldmann相关眼压[IOPg]）和GAT对这些参与者进行术后眼压测量。通过Bland-Altman分析计算设备一致性。使用ORA和CST记录角膜生物力学特性指标。比较角膜生物力学参数。
Bland-Altman分析显示，CST与GAT之间、CST与IOPcc之间以及CST与IOPg之间存在显著偏差，分别为3.4、1.0和3.8 mmHg，95%一致性界限分别为-0.7至7.5 mmHg、-2.1至4.2 mmHg和-0.4至8.0 mmHg。ORA得出的眼压测量值、CST得出的眼压值和GAT眼压值之间显示出良好的相关性。CST眼压和IOPcc高于GAT眼压（均p<0.05），而IOPg与GAT眼压读数无差异。眼反应分析仪得出的角膜生物力学参数（角膜滞后和角膜阻力因子）与CST得出的参数显著相关，包括角膜顶点的最大变形幅度和从开始到首次压平的时间。
CST为测量LASIK患者术后眼压提供了一种替代方法，并且它获得的眼压值似乎高于其他眼压测量技术。该技术可能有助于研究LASIK治疗眼的角膜生物力学特性变化。
