Kolesnikova Lubov, Semenova Natalya, Madaeva Irina, Suturina Larisa, Solodova Elena, Grebenkina Lyudmila, Darenskaya Marina
Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
Maturitas. 2015 May;81(1):83-7. doi: 10.1016/j.maturitas.2015.02.264. Epub 2015 Mar 7.
Menopause is a risk factor for oxidative stress. The aim of our study is to assess antioxidant system parameters (α-tocopherol, retinol, reduced glutathione, total antioxidant activity) in peri- and postmenopausal women. The antioxidant defense activity by estimation of total antioxidant activity, α-tocopherol, retinol, oxidized and reduced glutathione levels was studied in women of reproductive age (n=37), in perimenopausal (n=41) and postmenopausal women (n=41). In our study we used spectrofluorofotometer methods. Statistical analysis was performed by non-parametric tests with p<0.05 as the level of significance. The results of our study showed the decrease of α-tocopherol and retinol concentrations and the increase of oxidized glutathione level in blood serum both in perimenopausal and postmenopausal women, the total antioxidant activity of blood serum was decreased in postmenopausal women only. The results of our study demonstrate that decrease of antioxidant defense system resources depends on the menopausal phase.
更年期是氧化应激的一个风险因素。我们研究的目的是评估围绝经期和绝经后女性的抗氧化系统参数（α-生育酚、视黄醇、还原型谷胱甘肽、总抗氧化活性）。通过估计总抗氧化活性、α-生育酚、视黄醇、氧化型和还原型谷胱甘肽水平，对育龄期女性（n = 37）、围绝经期女性（n = 41）和绝经后女性（n = 41）的抗氧化防御活性进行了研究。在我们的研究中，使用了荧光分光光度计法。采用非参数检验进行统计分析，以p<0.05作为显著性水平。我们的研究结果显示，围绝经期和绝经后女性血清中α-生育酚和视黄醇浓度降低，氧化型谷胱甘肽水平升高，仅绝经后女性血清总抗氧化活性降低。我们的研究结果表明，抗氧化防御系统资源的减少取决于更年期阶段。
