放疗与免疫检查点抑制剂相辅相成。
Radiotherapy complements immune checkpoint blockade.
机构信息
Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia.
Cancer Therapeutics Programs, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
出版信息
Cancer Cell. 2015 Apr 13;27(4):437-8. doi: 10.1016/j.ccell.2015.03.015.
Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.
适应性免疫抵抗会削弱有效的抗肿瘤免疫反应。在最近的《自然》杂志上，Victor 及其同事描述了抗 PD-L1 在局部放射治疗加抗 CTLA-4 治疗时对抗适应性免疫抵抗的作用。放射治疗和双重免疫检查点阻断的优异活性是由癌症中非冗余的免疫机制介导的。
Zotero 插件