Zhang Yu, Wang Ruixia, Miao Limin, Zhu Longbiao, Jiang Hongbing, Yuan Hua
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Jiangsu Province, Nanjing, China.
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
PLoS One. 2015 Apr 13;10(4):e0124045. doi: 10.1371/journal.pone.0124045. eCollection 2015.
To provide a precise quantification of the association between alcohol and tobacco consumption trends in head and neck cancer patients over the past 45 years.
We combined findings from all studies published until March 2014 and evaluated the association between different levels in alcohol and tobacco consumption and head and neck cancers through a meta-analytic approach.
We included 28 studies involving 13830 patients with head and neck cancer. In patients with alcohol consumption, the pooled odds ratio (OR) and 95% confidence interval (CI) were 1.29(1.06-1.57), 2.67(2.05-3.48) and 6.63(5.02-8.74) for light drinkers, moderate drinkers and heavy drinkers, respectively. In patients with tobacco consumption, the pooled OR and 95% CI were 2.33(1.84-2.95), 4.97(3.67-6.71) and 6.77(4.81-9.53) for light smokers, moderate smokers and heavy smokers, respectively.
The increased alcohol and tobacco consumption trends increased the risk of head and neck cancer over the past 45 years. Tobacco consumption was found to be a stronger risk factor for head and neck cancer than alcohol consumption. Thus, the control should be considered to limit the intake of alcohol and tobacco.
精确量化过去45年中头颈部癌症患者饮酒与吸烟消费趋势之间的关联。
我们汇总了截至2014年3月发表的所有研究结果，并通过荟萃分析方法评估了不同水平的饮酒和吸烟消费与头颈部癌症之间的关联。
我们纳入了28项研究，涉及13830名头颈部癌症患者。在饮酒患者中，轻度饮酒者、中度饮酒者和重度饮酒者的合并比值比（OR）及95%置信区间（CI）分别为1.29（1.06 - 1.57）、2.67（2.05 - 3.48）和6.63（5.02 - 8.74）。在吸烟患者中，轻度吸烟者、中度吸烟者和重度吸烟者的合并OR及95%CI分别为2.33（1.84 - 2.95）、4.97（3.67 - 6.71）和6.77（4.81 - 9.53）。
在过去45年中，饮酒和吸烟消费趋势的增加增加了头颈部癌症的风险。研究发现，吸烟是比饮酒更强的头颈部癌症风险因素。因此，应考虑控制以限制烟酒摄入。
