Chowdhury P, Hosotani R, Rayford P L
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences Little Rock 72205.
Pharmacol Biochem Behav. 1989 Jul;33(3):591-4. doi: 10.1016/0091-3057(89)90393-6.
This study was undertaken in male Sprague-Dawley rats to test the hypothesis that chronic ingestion of a low dose of nicotine suppresses body weight gain. The results from this study suggest that chronic nicotine ingestion induces weight loss in rats without the loss of their food intake. To determine whether the nicotine-induced body weight reductions are associated with endocrinological changes, the levels of gastrin and CCK in plasma were measured by specific radioimmunoassays and were found significantly elevated during chronic ingestion of nicotine. The data indicate that reduction of body weight mass by nicotine might be dependent on both hormonal and metabolic factors.
本研究以雄性Sprague-Dawley大鼠为对象，以验证长期摄入低剂量尼古丁会抑制体重增加这一假说。该研究结果表明，长期摄入尼古丁会导致大鼠体重减轻，但食物摄入量并未减少。为了确定尼古丁引起的体重减轻是否与内分泌变化有关，通过特定的放射免疫分析法测定了血浆中胃泌素和胆囊收缩素的水平，发现长期摄入尼古丁期间这些水平显著升高。数据表明，尼古丁导致的体重减轻可能取决于激素和代谢因素。
