Liu Yao, Sun Yan, Ding Guanglong, Geng Qianqian, Zhu Juanli, Guo Mingcheng, Duan Yongheng, Wang Baitao, Cao Yongsong
College of Agriculture and Biotechnology, China Agricultural University, 2 Yuanmingyuan West Road, Beijing, China.
J Agric Food Chem. 2015 May 6;63(17):4263-8. doi: 10.1021/jf5055062. Epub 2015 Apr 27.
The controlled and targeted release of pesticides with high water solubility has been a challenge for integrated pest management. In this paper, kasugamycin, an antibiotic broadly used in plant disease control, was covalently conjugated to pectin to form a kasugamycin-pectin conjugate by an amide bond. The conjugate was structurally characterized by Fourier transform infrared spectroscopy, ultraviolet spectrophotometry, and thermal gravimetric analysis. The results showed that the conjugate was stable over a wide range of pH and temperatures, as well as under UV irradiation. When incubated with Pseudomonas syringae pv. lachrymans, the conjugate could be activated, releasing the kasugamycin, which made it a promising controlled-release formulation of pesticide.
高水溶性农药的控释和靶向释放一直是害虫综合治理中的一项挑战。本文中，将广泛用于植物病害防治的抗生素春雷霉素通过酰胺键与果胶共价偶联，形成春雷霉素-果胶共轭物。通过傅里叶变换红外光谱、紫外分光光度法和热重分析对该共轭物进行了结构表征。结果表明，该共轭物在较宽的pH值、温度范围内以及紫外线照射下均稳定。当与黄瓜细菌性角斑病菌一起培养时，该共轭物可被激活，释放出春雷霉素，这使其成为一种很有前景的农药控释制剂。
