Huang Yanmin, Li Xiangying, Xiong Qipeng, Chen Yong, Peng Zining, Chen Jinghong, Li Junyan, Zhang Yuanfei, Cui Jianguo
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, PR China.
Guangxi Tianyuan Biochemical Company Limited, Nanning 530001, PR China.
ACS Omega. 2022 Aug 9;7(33):29046-29053. doi: 10.1021/acsomega.2c02883. eCollection 2022 Aug 23.
Controlled release formulations (CRFs) are considered an effective way to solve the low bioavailability of traditional pesticides. However, CRFs prepared by coating or encapsulation has the disadvantage of explosive release of the ingredients. Sustained-release pesticides prepared by coupling with a carrier can overcome this shortcoming. In the present study, an emamectin-lignin sulfonic acid conjugate (EB-SL), in which emamectin was connected sulfonamide bonds with lignin, was prepared using sodium lignosulfonate as the carrier. The structure of the conjugate was characterized by IR, HNMR, and elemental analysis. The sustained-release results showed that EB-SL maintained its original structure when released in pure water and soil columns, and the sulfamide bond did not break. The photolysis test displayed that the photolysis half-life of EB-SL was increased by 1.5 times compared with the emamectin suspending concentrate (EB-SC). Bioactivity tests in the greenhouse showed that EB-SL not only had similar insecticidal toxicity to emamectin emulsion concentrate (EB-EC) against but also displayed a longer duration. The lethality of EB-SL on was maintained at more than 70% across 19 days, whereas EB-EC as the control was less than 50% after 11 days of application.
控释制剂（CRFs）被认为是解决传统农药生物利用度低的有效方法。然而，通过包衣或封装制备的控释制剂存在成分爆发式释放的缺点。与载体偶联制备的缓释农药可以克服这一缺点。在本研究中，以木质素磺酸钠为载体，制备了一种甲氨基阿维菌素苯甲酸盐-木质素磺酸共轭物（EB-SL），其中甲氨基阿维菌素苯甲酸盐通过磺酰胺键与木质素相连。通过红外光谱（IR）、核磁共振氢谱（HNMR）和元素分析对共轭物的结构进行了表征。缓释结果表明，EB-SL在纯水和土柱中释放时保持其原始结构，磺酰胺键未断裂。光解试验表明，与甲氨基阿维菌素苯甲酸盐悬浮剂（EB-SC）相比，EB-SL的光解半衰期增加了1.5倍。温室生物活性试验表明，EB-SL不仅对甲氨基阿维菌素苯甲酸盐乳油（EB-EC）具有相似的杀虫毒性，而且持效期更长。EB-SL对[具体害虫名称未给出]的致死率在19天内保持在70%以上，而作为对照的EB-EC在施药11天后低于50%。
