Franz Johannes F, Kraus Wolfgang B, Zeitler Kirsten
Institut für Organische Chemie, Universität Leipzig, D-04103 Leipzig, Germany.
Chem Commun (Camb). 2015 May 14;51(39):8280-3. doi: 10.1039/c4cc10270c.
A visible light mediated, but photocatalyst-free method for the oxidative α-CH functionalization of tertiary amines with a broad scope of carbon- and heteroatom nucleophiles using polyhalomethanes has been developed. In addition, the pivotal visible light triggered activation of polyhalomethanes offers mild conditions for efficient Kharasch-type additions onto non-activated olefins. Preliminary mechanistic studies are reported.
已开发出一种可见光介导但无光催化剂的方法，用于叔胺的氧化α-碳官能化反应，该反应可使用多卤代甲烷与多种碳亲核试剂和杂原子亲核试剂进行反应。此外，可见光引发的多卤代甲烷的关键活化作用为在未活化烯烃上进行高效的卡拉施型加成反应提供了温和的条件。本文报道了初步的机理研究。
