Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Org Biomol Chem. 2020 Mar 18;18(11):2103-2112. doi: 10.1039/c9ob02699a.
A visible-light-mediated process for dehydrogenation of amines has been described. The given protocol showed a broad substrate scope, mild reaction conditions and excellent results without the requirement of tedious purification. This process can be applied in one-pot functionalization of secondary amines with various nucleophiles through the cooperation of visible-light and Lewis acid catalysis, leading to the structurally varied essential components of biologically active molecules. In addition, Stern-Volmer studies and quenching experiments revealed the role of a catalyst and led to the proposed mechanism of this transformation.
一种可见光介导的胺脱氢反应过程已经被描述。该方法具有广泛的底物适用范围、温和的反应条件和优异的结果，无需繁琐的纯化。该过程可以通过可见光和路易斯酸催化的协同作用，在一锅法中实现仲胺与各种亲核试剂的功能化，得到生物活性分子中结构多样的必需成分。此外，Stern-Volmer 研究和淬灭实验揭示了催化剂的作用，并提出了这种转化的机理。
