Tierney Peyton A, Karpinski Clarissa D, Brown Jessica E, Luo Wentai, Pankow James F
Department of Civil and Environmental Engineering, Portland State University, Portland, Oregon, USA.
Department of Chemistry, Portland State University, Portland, Oregon, USA.
Tob Control. 2016 Apr;25(e1):e10-5. doi: 10.1136/tobaccocontrol-2014-052175. Epub 2015 Apr 15.
Most e-cigarette liquids contain flavour chemicals. Flavour chemicals certified as safe for ingestion by the Flavor Extracts Manufacturers Association may not be safe for use in e-cigarettes. This study identified and measured flavour chemicals in 30 e-cigarette fluids.
Two brands of single-use e-cigarettes were selected and their fluids in multiple flavour types analysed by gas chromatography/mass spectrometry. For the same flavour types, and for selected confectionary flavours (eg, bubble gum and cotton candy), also analysed were convenience samples of e-cigarette fluids in refill bottles from local 'vape' shops and online retailers.
In many liquids, total flavour chemicals were found to be in the ∼1-4% range (10-40 mg/mL); labelled levels of nicotine were in the range of 0.6-2.4% (6 to 24 mg/mL). A significant number of the flavour chemicals were aldehydes, a compound class recognised as 'primary irritants' of mucosal tissue of the respiratory tract. Many of the products contained the same flavour chemicals: vanillin and/or ethyl vanillin was found in 17 of the liquids as one of the top three flavour chemicals, and/or at ≥0.5 mg/mL.
The concentrations of some flavour chemicals in e-cigarette fluids are sufficiently high for inhalation exposure by vaping to be of toxicological concern. Regulatory limits should be contemplated for levels of some of the more worrisome chemicals as well as for total flavour chemical levels. Ingredient labeling should also be required.
大多数电子烟液含有调味化学品。经香料提取物制造商协会认证可安全摄入的调味化学品，用于电子烟时可能并不安全。本研究鉴定并测量了30种电子烟液中的调味化学品。
选择两个品牌的一次性电子烟，通过气相色谱/质谱法分析其多种口味类型的烟液。对于相同的口味类型，以及选定的糖果口味（如泡泡糖和棉花糖），还分析了从当地“电子烟”商店和在线零售商购买的瓶装补充装电子烟液的便利样本。
在许多烟液中，调味化学品总量在1%至4%的范围内（10 - 40毫克/毫升）；尼古丁的标注含量在0.6%至2.4%的范围内（6至24毫克/毫升）。大量调味化学品为醛类，这是一类被认为是呼吸道黏膜组织“主要刺激物”的化合物。许多产品含有相同的调味化学品：17种烟液中发现香草醛和/或乙基香草醛是含量最高的三种调味化学品之一，且含量≥0.5毫克/毫升。
电子烟液中某些调味化学品的浓度足够高，通过吸电子烟吸入这些化学品会引发毒理学问题。应考虑对一些更令人担忧的化学品的含量以及调味化学品总量设定监管限值。还应要求进行成分标注。
