Guan Jiahao, Dong Yihan, Zhang Wenli, Gui Qiaodi, Luo Danxia, Wen Hongxia, Dang Xiaojun, Liang Daoyan, Hu Shuling, Zhang Yaqin, Liao Guimei, Zhang Lixia, Lu Zifan
Department of Clinical Laboratory, Shaanxi Provincial People's Hospital, Xi 'an, 710068, People's Republic of China.
Medical College, Yan' an University, Yan' an, Shaanxi, 716000, People's Republic of China.
Int J Womens Health. 2024 Dec 6;16:2103-2112. doi: 10.2147/IJWH.S481539. eCollection 2024.
Vaginitis is a common disease of the reproductive system in women, causing discomfort in daily life. Many reports indicate that the causes of vaginitis are related to vaginal microecological disturbances. Therefore, treatment strategies to restore microecological balance have shown promising results in both basic research and clinical settings. Recent studies have highlighted the potential adjuvant role of vitamin D in the treatment of vaginitis while illustrating its role in maintaining microecological balance. Therefore, this study focused on the therapeutic effects of vitamin D on vaginitis.
The study provided a statistical description of 5978 vaginitis patients who visited Shaanxi Provincial People's Hospital, presenting data in absolute numbers (%) and mean ± standard deviation (median quartiles were used for non-normally distributed variables). The chi-square test and analysis of variance were employed to analyze the distribution of vitamin D levels among patients, factors influencing vitamin D levels, and the association between recurrence rates and vitamin D levels.
Vitamin D deficiency (57.74%) or insufficiency (22.20%) is prevalent among patients with vaginitis. Furthermore, vitamin D levels have an impact on the dominant bacterial species in the vagina, as well as catalase, acetylglucosaminidase, and the overall vaginal microecological status. Age and BMI have correlations with vitamin D levels. It is hypothesized that this relationship may be attributed to clinicians utilizing vitamin D as a supplementary treatment.
This study examined the statistical findings of vitamin D-related data from 5978 vaginitis patients, revealing a positive correlation between vitamin D deficiency and vaginitis occurrence. Patients with vitamin D deficiency/severe deficiency showed weakly positive levels of catalase and mostly weakly positive levels of acetylglucosaminidase, and most of these vaginitis are trichomonas vaginalis (TV). Furthermore, older individuals and those with higher BMI were found to be more susceptible to symptoms of vitamin D deficiency.
阴道炎是女性生殖系统的常见疾病，给日常生活带来不适。许多报告表明，阴道炎的病因与阴道微生态紊乱有关。因此，恢复微生态平衡的治疗策略在基础研究和临床环境中均显示出有前景的结果。最近的研究强调了维生素D在阴道炎治疗中的潜在辅助作用，同时阐明了其在维持微生态平衡中的作用。因此，本研究聚焦于维生素D对阴道炎的治疗效果。
该研究对5978例就诊于陕西省人民医院的阴道炎患者进行了统计描述，以绝对数（%）和均值±标准差呈现数据（非正态分布变量使用中位数四分位数）。采用卡方检验和方差分析来分析患者中维生素D水平的分布、影响维生素D水平的因素以及复发率与维生素D水平之间的关联。
阴道炎患者中维生素D缺乏（57.74%）或不足（22.20%）很普遍。此外，维生素D水平对阴道中的优势菌种、过氧化氢酶、乙酰氨基葡萄糖苷酶以及整体阴道微生态状况均有影响。年龄和体重指数与维生素D水平相关。据推测，这种关系可能归因于临床医生将维生素D用作辅助治疗。
本研究检查了5978例阴道炎患者维生素D相关数据的统计结果，揭示了维生素D缺乏与阴道炎发生之间存在正相关。维生素D缺乏/严重缺乏的患者过氧化氢酶水平呈弱阳性，乙酰氨基葡萄糖苷酶大多呈弱阳性，且这些阴道炎大多为滴虫性阴道炎（TV）。此外，发现年龄较大者和体重指数较高者更容易出现维生素D缺乏症状。
