Tecilazich Francesco, Kafanas Antonios, Veves Aristidis
Research Fellow, Joslin-Beth Israel Deaconess Foot Center and Microcirculation Lab, Harvard Medical School, Boston, Massachusetts.
General Hospital of Serres, Greece.
Wounds. 2011 Jul;23(7):192-203.
Dermatological problems occur with increased frequency in individuals with diabetes mellitus (DM). Cutaneous manifestations may be the first presenting sign of DM or even precede the diagnosis by many years. The main changes in the skin are due to alterations of microcirculation, the nervous system, and collagen. The most common skin problems in DM are acanthosis nigricans, necrobiosis lipoidica, diabetic dermopathy, scleredema, and granuloma anulare. The purpose of this review is to describe the molecular and anatomopathological alterations occurring at the skin during DM, and to illustrate the most important and common clinical skin manifestations in patients with DM. .
糖尿病患者的皮肤问题发生率更高。皮肤表现可能是糖尿病的首发症状，甚至可能在诊断前数年就已出现。皮肤的主要变化归因于微循环、神经系统和胶原蛋白的改变。糖尿病最常见的皮肤问题是黑棘皮病、类脂质渐进性坏死、糖尿病性皮肤病、硬化性水肿和环状肉芽肿。本综述的目的是描述糖尿病期间皮肤发生的分子和解剖病理学改变，并阐述糖尿病患者最重要和最常见的临床皮肤表现。
