Wang An-Ran, Song Hong-Chuan, An Hong-Mei, Huang Qian, Luo Xie, Dong Jin-Yan
Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Science, Southwest University, Chongqing 400715, P. R. China, (phone: +86-23-68252400; fax: +86-23-68252365).
Chem Biodivers. 2015 Apr;12(4):451-73. doi: 10.1002/cbdv.201300376.
Chloranthus, a genus of the family Chloranthaceae, which is mainly distributed in eastern and southern Asia, has been used in Chinese folk medicine due to its antitumor, antifungal, and anti-inflammatory activities. This review compiles the research on isolation, structure elucidation, structural diversity, and bioactivities of Chloranthus secondary metabolites reported between 2007 and 2013. The metabolites listed encompass 82 sesquiterpenoids, 50 dimeric sesquiterpenoids, 15 diterpenoids, one coumarin, and five other compounds. Among them, dimeric sesquiterpenoids, the characteristic components of plants from the genus Chloranthus, have attracted considerable attention due to their complex structures and significant biological features, e.g., antitumor, antibacterial, antifungal, anti-inflammatory, and hepatoprotective activities, and potent and selective inhibition of the delayed rectifier (IK) K(+) current and tyrosinase.
金粟兰属是金粟兰科的一个属，主要分布于亚洲东部和南部，因其具有抗肿瘤、抗真菌和抗炎活性而被用于中国民间医学。本综述汇编了2007年至2013年间报道的金粟兰次生代谢产物的分离、结构解析、结构多样性和生物活性的研究。列出的代谢产物包括82种倍半萜、50种二聚倍半萜、15种二萜、1种香豆素和5种其他化合物。其中，二聚倍半萜作为金粟兰属植物的特征成分，因其结构复杂和显著的生物学特性，如抗肿瘤、抗菌、抗真菌、抗炎和保肝活性，以及对延迟整流钾电流（IK）和酪氨酸酶的强效和选择性抑制，而备受关注。
