McLean Kendra, Day Lesley, Dalton Andrew
Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Bentleigh Bayside Community Health, PO Box 30, Bentleigh East, 3165, Victoria, Australia.
BMC Geriatr. 2015 Mar 26;15:33. doi: 10.1186/s12877-015-0028-x.
Falls among older people are of growing concern globally. Implementing cost-effective strategies for their prevention is of utmost importance given the ageing population and associated potential for increased costs of fall-related injury over the next decades. The purpose of this study was to undertake a cost-utility analysis and secondary cost-effectiveness analysis from a healthcare system perspective, of a group-based exercise program compared to routine care for falls prevention in an older community-dwelling population.
A decision analysis using a decision tree model was based on the results of a previously published randomised controlled trial with a community-dwelling population aged over 70. Measures of falls, fall-related injuries and resource use were directly obtained from trial data and supplemented by literature-based utility measures. A sub-group analysis was performed of women only. Cost estimates are reported in 2010 British Pound Sterling (GBP).
The ICER of GBP£51,483 per QALY for the base case analysis was well above the accepted cost-effectiveness threshold of GBP£20,000 to £30,000 per QALY, but in a sensitivity analysis with minimised program implementation the incremental cost reached GBP£25,678 per QALY. The ICER value at 95% confidence in the base case analysis was GBP£99,664 per QALY and GBP£50,549 per QALY in the lower cost analysis. Males had a 44% lower injury rate if they fell, compared to females resulting in a more favourable ICER for the women only analysis. For women only the ICER was GBP£22,986 per QALY in the base case and was below the cost-effectiveness threshold for all other variations of program implementation. The ICER value at 95% confidence was GBP£48,212 in the women only base case analysis and GBP£23,645 in the lower cost analysis. The base case incremental cost per fall averted was GBP£652 (GBP£616 for women only). A threshold analysis indicates that this exercise program cannot realistically break even.
The results suggest that this exercise program is cost-effective for women only. There is no evidence to support its cost-effectiveness in a group of mixed gender unless the costs of program implementation are minimal. Conservative assumptions may have underestimated the true cost-effectiveness of the program.
老年人跌倒问题在全球范围内日益受到关注。鉴于人口老龄化以及未来几十年与跌倒相关伤害成本增加的潜在可能性,实施具有成本效益的预防策略至关重要。本研究的目的是从医疗保健系统的角度,对一项基于群体的运动计划与常规护理在预防老年社区居住人群跌倒方面进行成本效用分析和二次成本效益分析。
使用决策树模型进行决策分析,该模型基于先前发表的一项针对70岁以上社区居住人群的随机对照试验结果。跌倒、跌倒相关伤害和资源使用的测量数据直接从试验数据中获取,并辅以基于文献的效用测量。仅对女性进行了亚组分析。成本估计以2010年英镑(GBP)报告。
基础案例分析中每获得一个质量调整生命年(QALY)的增量成本效益比(ICER)为51,483英镑,远高于公认的每QALY 20,000至30,000英镑的成本效益阈值,但在项目实施成本最小化的敏感性分析中,每QALY的增量成本达到25,678英镑。基础案例分析中95%置信度下的ICER值为每QALY 99,664英镑,低成本分析中为每QALY 50,549英镑。男性跌倒后的受伤率比女性低44%,这使得仅对女性进行分析时的ICER更有利。仅对女性而言,基础案例中每QALY的ICER为22,986英镑,低于项目实施所有其他变体的成本效益阈值。仅对女性进行的基础案例分析中95%置信度下的ICER值为48,212英镑,低成本分析中为23,645英镑。基础案例中每避免一次跌倒的增量成本为652英镑(仅对女性而言为616英镑)。阈值分析表明,该运动计划实际上无法实现收支平衡。
结果表明,该运动计划仅对女性具有成本效益。没有证据支持其在混合性别群体中的成本效益,除非项目实施成本极低。保守的假设可能低估了该计划的实际成本效益。