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一项针对社区居住老年人量身定制的多因素预防跌倒的随机对照试验的成本效益分析。

A Cost-Effectiveness Analysis of a Randomized Control Trial of a Tailored, Multifactorial Program to Prevent Falls Among the Community-Dwelling Elderly.

机构信息

Program in Health Services and Systems Research, Duke NUS Medical School, Singapore; Department of Internal Medicine (General Internal Medicine), Duke University Medical Center, Durham, NC.

Program in Health Services and Systems Research, Duke NUS Medical School, Singapore; Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.

出版信息

Arch Phys Med Rehabil. 2019 Jan;100(1):1-8. doi: 10.1016/j.apmr.2018.07.434. Epub 2018 Aug 27.

Abstract

OBJECTIVE

To perform a cost-effectiveness analysis of a multifactorial, tailored intervention to reduce falls among a heterogeneous group of high-risk elderly people.

DESIGN

Randomized control trial.

SETTINGS

Communities.

PARTICIPANTS

Adults aged at least 65 years (N=354) seen at the emergency department (ED) for a fall or fall-related injury and discharged home.

INTERVENTIONS

The intervention group received a tailored program of physical therapy focused on progressive training in strength, balance, and gait for a period of 3 months. They also received screening and referrals for low vision, polypharmacy, and environmental hazards. The Short Physical Performance Battery (SPPB) test was assessed at regular intervals to allocate participants into either a home-based or group center-based program. The control group received usual care prescribed by a physician and educational materials on falls prevention.

MAIN OUTCOME MEASURES

The incremental cost-effectiveness ratio (ICER) over the 9-month study period based on intervention costs and utility in terms of quality-adjusted life years (QALYs) calculated from EuroQol-5D scores.

RESULTS

The ICER was 120,667 Singapore dollars (S$) per QALY gained (S$362/0.003 QALYs), above benchmark values (S$70,000). However, the intervention was more effective and cost-saving among those with SPPB scores of greater than 6 at baseline, higher cognitive function, better vision and no more than 1 fall in the preceding 6 months. The intervention was also cost-effective among those with 0-1 critical comorbidities (S$22,646/QALY).

CONCLUSION

The intervention was, overall, not cost-effective, compared to usual care. However, the program was cost-effective among healthier subgroups, and even potentially cost-saving among individuals with sufficient reserve to benefit.

摘要

目的

对一项多因素、个体化干预措施进行成本效益分析,以降低异质高危老年人跌倒的发生率。

设计

随机对照试验。

地点

社区。

参与者

至少 65 岁的成年人(N=354)因跌倒或与跌倒相关的损伤而到急诊科就诊,并被送回家中。

干预措施

干预组接受了一项个体化的物理治疗计划,重点是在 3 个月的时间内进行力量、平衡和步态的渐进式训练。他们还接受了低视力、多种药物治疗和环境危害的筛查和转诊。定期评估短体适能表现测试(SPPB),以将参与者分配到家庭或团体中心的方案中。对照组接受医生规定的常规护理和预防跌倒的教育材料。

主要观察指标

基于干预成本和健康调整生命年(QALYs)的效用(根据 EuroQol-5D 评分计算),在 9 个月的研究期间,增量成本效益比(ICER)。

结果

干预组的每获得一个质量调整生命年(QALY)的增量成本效益比(ICER)为 120667 新加坡元(S$)(S$362/0.003 QALYs),高于基准值(S$70000)。然而,在基线 SPPB 评分大于 6、认知功能较高、视力较好且在过去 6 个月内跌倒次数不超过 1 次的患者中,干预措施更为有效且节省成本。在有 0-1 种严重合并症的患者中,干预措施也具有成本效益(每获得一个质量调整生命年(QALY)的成本为 22646 新加坡元)。

结论

与常规护理相比,该干预措施总体上不具有成本效益。然而,在更健康的亚组中,该方案具有成本效益,甚至对具有足够储备获益的个体可能具有成本节约效果。

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