Program in Health Services and Systems Research, Duke NUS Medical School, Singapore; Department of Internal Medicine (General Internal Medicine), Duke University Medical Center, Durham, NC.
Program in Health Services and Systems Research, Duke NUS Medical School, Singapore; Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.
Arch Phys Med Rehabil. 2019 Jan;100(1):1-8. doi: 10.1016/j.apmr.2018.07.434. Epub 2018 Aug 27.
To perform a cost-effectiveness analysis of a multifactorial, tailored intervention to reduce falls among a heterogeneous group of high-risk elderly people.
Randomized control trial.
Communities.
Adults aged at least 65 years (N=354) seen at the emergency department (ED) for a fall or fall-related injury and discharged home.
The intervention group received a tailored program of physical therapy focused on progressive training in strength, balance, and gait for a period of 3 months. They also received screening and referrals for low vision, polypharmacy, and environmental hazards. The Short Physical Performance Battery (SPPB) test was assessed at regular intervals to allocate participants into either a home-based or group center-based program. The control group received usual care prescribed by a physician and educational materials on falls prevention.
The incremental cost-effectiveness ratio (ICER) over the 9-month study period based on intervention costs and utility in terms of quality-adjusted life years (QALYs) calculated from EuroQol-5D scores.
The ICER was 120,667 Singapore dollars (S$) per QALY gained (S$362/0.003 QALYs), above benchmark values (S$70,000). However, the intervention was more effective and cost-saving among those with SPPB scores of greater than 6 at baseline, higher cognitive function, better vision and no more than 1 fall in the preceding 6 months. The intervention was also cost-effective among those with 0-1 critical comorbidities (S$22,646/QALY).
The intervention was, overall, not cost-effective, compared to usual care. However, the program was cost-effective among healthier subgroups, and even potentially cost-saving among individuals with sufficient reserve to benefit.
对一项多因素、个体化干预措施进行成本效益分析,以降低异质高危老年人跌倒的发生率。
随机对照试验。
社区。
至少 65 岁的成年人(N=354)因跌倒或与跌倒相关的损伤而到急诊科就诊,并被送回家中。
干预组接受了一项个体化的物理治疗计划,重点是在 3 个月的时间内进行力量、平衡和步态的渐进式训练。他们还接受了低视力、多种药物治疗和环境危害的筛查和转诊。定期评估短体适能表现测试(SPPB),以将参与者分配到家庭或团体中心的方案中。对照组接受医生规定的常规护理和预防跌倒的教育材料。
基于干预成本和健康调整生命年(QALYs)的效用(根据 EuroQol-5D 评分计算),在 9 个月的研究期间,增量成本效益比(ICER)。
干预组的每获得一个质量调整生命年(QALY)的增量成本效益比(ICER)为 120667 新加坡元(S$)(S$362/0.003 QALYs),高于基准值(S$70000)。然而,在基线 SPPB 评分大于 6、认知功能较高、视力较好且在过去 6 个月内跌倒次数不超过 1 次的患者中,干预措施更为有效且节省成本。在有 0-1 种严重合并症的患者中,干预措施也具有成本效益(每获得一个质量调整生命年(QALY)的成本为 22646 新加坡元)。
与常规护理相比,该干预措施总体上不具有成本效益。然而,在更健康的亚组中,该方案具有成本效益,甚至对具有足够储备获益的个体可能具有成本节约效果。