Reinbold W D, Wannenmacher M, Hodapp N, Adler C P
Department of Diagnostic Radiology, University of Freiburg, Federal Republic of Germany.
Skeletal Radiol. 1989;18(7):517-21. doi: 10.1007/BF00351751.
Bone density has been assessed during and after radiotherapy of metastases of the spine using quantitative computed tomography (QCT) in 19 patients with osteolytic vertebral lesions. All patients underwent external photon radiation with a total dose of 40 Gy over a period of 4 weeks. Measurements of vertebral mineral density were performed at the beginning, at the end, and 3 months after radiotherapy. In 13 patients with osteolytic metastases, radiotherapy achieved complete release of pain; it was unsuccessful in the remaining 6 patients. Immediately after successful radiotherapy, osteolytic metastases showed a decrease of bone density of 24.7% followed by an increase of 60.6% 3 months later. Normal bone surrounding the osteolysis showed an increase of density at the end and 3 months after radiotherapy. QCT has proved to be a helpful tool in assessing successful radiotherapy of metastases of the spine.
采用定量计算机断层扫描（QCT）对19例溶骨性椎体病变患者脊柱转移瘤放疗期间及放疗后的骨密度进行了评估。所有患者均接受外照射光子放疗，4周内总剂量为40 Gy。在放疗开始时、结束时及放疗后3个月进行椎体骨密度测量。13例溶骨性转移瘤患者放疗后疼痛完全缓解；其余6例患者治疗失败。成功放疗后，溶骨性转移瘤骨密度立即下降24.7%，3个月后增加60.6%。溶骨周围的正常骨在放疗结束时及放疗后3个月骨密度增加。QCT已被证明是评估脊柱转移瘤放疗效果的有用工具。
