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巨大恶性叶状乳腺肿瘤：早期乳腺癌新时代的一个真实实体。

Huge malignant phyllodes breast tumor: a real entity in a new era of early breast cancer.

作者信息

Testori Alberto, Meroni Stefano, Errico Valentina, Travaglini Roberto, Voulaz Emanuele, Alloisio Marco

机构信息

Department of Thoracic and General Surgery, Humanitas Research Hospital, Via Manzoni, 56, Rozzano, Milan, Italy.

Division of Breast Radiology, European Institute of Oncology, Via Ripamonti, 435, Milan, Italy.

出版信息

World J Surg Oncol. 2015 Feb 27;13:81. doi: 10.1186/s12957-015-0508-7.

DOI:10.1186/s12957-015-0508-7
PMID:25880837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4350953/
Abstract

Phyllodes tumor is an extremely rare tumor of the breast. It occurs in females in the third and fourth decades. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. Lymph node involvement is rarely described in phyllodes tumors; for this reason, sentinel node biopsy may be warranted. We present a case of a 33-year-old woman affected by huge tumor of the right breast with ulceration in the skin with a rapid tumor growth and with omolateral axillary metastasis.

摘要

叶状肿瘤是一种极其罕见的乳腺肿瘤。它发生于三四十岁的女性。叶状肿瘤与良性纤维腺瘤难以区分，这可能导致误诊。叶状肿瘤很少有淋巴结受累的描述；因此，前哨淋巴结活检可能是必要的。我们报告一例33岁女性，患有右侧乳腺巨大肿瘤，皮肤有溃疡，肿瘤生长迅速，且有同侧腋窝转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904b/4350953/4a0b31f88b8c/12957_2015_508_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904b/4350953/2dbfc39e0c14/12957_2015_508_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904b/4350953/4a0b31f88b8c/12957_2015_508_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904b/4350953/2dbfc39e0c14/12957_2015_508_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/904b/4350953/4a0b31f88b8c/12957_2015_508_Fig2_HTML.jpg

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本文引用的文献

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Challenges in management of phyllodes tumors of the breast: a retrospective analysis of 150 patients.乳腺叶状肿瘤的管理挑战：150例患者的回顾性分析
Indian J Cancer. 2013 Oct-Dec;50(4):345-8. doi: 10.4103/0019-509X.123625.
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Breast phyllodes tumor: a review of literature and a single center retrospective series analysis.乳腺叶状肿瘤：文献复习及单中心回顾性系列分析。
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Malignant phyllodes tumors: a review of 752 cases.恶性叶状肿瘤：752例病例回顾
最初诊断为瘢痕疙瘩的叶状肿瘤。
BMJ Case Rep. 2023 May 2;16(5):e250546. doi: 10.1136/bcr-2022-250546.
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Giant Malignant Phyllode Tumor: A Case Report.巨大恶性叶状肿瘤：一例报告
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Malignant Phyllodes Tumor of the Breast and Pregnancy: A Rare Case Report and Literature Review.乳腺恶性叶状肿瘤与妊娠：罕见病例报告及文献复习。
Medicina (Kaunas). 2021 Dec 26;58(1):36. doi: 10.3390/medicina58010036.
6
Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers.两例进展性乳腺叶状肿瘤存在其他晚期癌症中常见的基因改变。
Orphanet J Rare Dis. 2021 Aug 16;16(1):363. doi: 10.1186/s13023-021-01986-z.
7
Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature.巨大良性乳腺叶状肿瘤：1例报告并文献复习
Case Rep Oncol. 2021 Mar 1;14(1):123-133. doi: 10.1159/000510741. eCollection 2021 Jan-Apr.
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Surg Case Rep. 2020 Dec 7;6(1):308. doi: 10.1186/s40792-020-00986-8.
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Indian J Surg Oncol. 2020 Sep;11(3):423-432. doi: 10.1007/s13193-020-01107-5. Epub 2020 Jun 3.
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Asian Pac J Cancer Prev. 2020 Sep 1;21(9):2653-2659. doi: 10.31557/APJCP.2020.21.9.2653.
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