水杉中一种松香烷型二萜紫杉醌对α-葡萄糖苷酶和酪氨酸酶的抑制作用。
α-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides.
作者信息
Bajpai Vivek K, Park Yong-Ha, Na MinKyun, Kang Sun Chul
机构信息
Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, Korea.
College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea.
出版信息
BMC Complement Altern Med. 2015 Mar 26;15:84. doi: 10.1186/s12906-015-0626-3.
BACKGROUND
Nowadays plant derived natural compounds have gained huge amount of research attention especially in food and medicine industries due to their multitude of biological and therapeutic properties as alternative medicines.
METHODS
In this study, a diterpenoid compound taxoquinone, isolated from Metasequoia glyptostroboides was evaluated for its α-glucosidase and tyrosinase inhibitory efficacy in terms of its potent anti-diabetic and depigmentation potential, respectively.
RESULTS
As a result, taxoquinone at the concentration range of 100-3,000 μg/mL and 200-1,000 μg/mL showed potent efficacy on inhibiting α-glucosidase and tyrosinase enzymes by 9.24-51.32% and 11.14-52.32%, respectively.
CONCLUSIONS
The findings of this study clearly evident potent therapeutic efficacy of an abietane diterpenoid taxoquinone isolated from M. glyptostroboides with a possibility for using it as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent.
背景
如今，植物源天然化合物因其作为替代药物的多种生物学和治疗特性，在食品和医药行业获得了大量研究关注。
方法
在本研究中，从水杉中分离出的二萜类化合物紫杉醌，分别就其强大的抗糖尿病和色素沉着抑制潜力，评估了其对α - 葡萄糖苷酶和酪氨酸酶的抑制效果。
结果
结果表明，浓度范围为100 - 3000μg/mL的紫杉醌对α - 葡萄糖苷酶的抑制率为9.24% - 51.32%，浓度范围为200 - 1000μg/mL的紫杉醌对酪氨酸酶的抑制率为11.14% - 52.32%。
结论
本研究结果清楚地表明，从水杉中分离出的枞烷二萜类紫杉醌具有强大的治疗效果，有可能作为预防2型糖尿病相关疾病的天然替代药物以及色素沉着抑制剂，在食品和医药行业用作新型候选药物。
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