van Erp Theo G M, Preda Adrian, Turner Jessica A, Callahan Shawn, Calhoun Vince D, Bustillo Juan R, Lim Kelvin O, Mueller Bryon, Brown Gregory G, Vaidya Jatin G, McEwen Sarah, Belger Aysenil, Voyvodic James, Mathalon Daniel H, Nguyen Dana, Ford Judith M, Potkin Steven G
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
Psychiatry Res. 2015 Dec 30;230(3):826-34. doi: 10.1016/j.psychres.2015.10.028. Epub 2015 Oct 26.
Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS(®)). Neurocognitive domain z-scores were computed from computerized neuropsychological tests, similar to those in the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB), administered to 175 patients with schizophrenia and 169 demographically similar healthy volunteers. The schizophrenia domain profile order by effect size was Speed of Processing (d=-1.14), Attention/Vigilance (d=-1.04), Working Memory (d=-1.03), Verbal Learning (d=-1.02), Visual Learning (d=-0.91), and Reasoning/Problem Solving (d=-0.67). There were no significant group by sex interactions, but overall women, compared to men, showed advantages on Attention/Vigilance, Verbal Learning, and Visual Learning compared to Reasoning/Problem Solving on which men showed an advantage over women. The CMINDS can readily be employed in the assessment of cognitive deficits in neuropsychiatric disorders; particularly in large-scale studies that may benefit most from electronic data capture.
精神分裂症的神经认知领域概况主要基于纸笔测试组合。本研究呈现了首个基于计算机化多相交互式神经认知系统（CMINDS(®)）的精神分裂症领域概况。从计算机化神经心理测试中计算神经认知领域的z分数，这些测试类似于精神分裂症认知改善测量与治疗研究共识认知测试组合（MCCB）中的测试，对175名精神分裂症患者和169名人口统计学特征相似的健康志愿者进行了测试。按效应大小排列的精神分裂症领域概况顺序为：加工速度（d = -1.14）、注意力/警觉性（d = -1.04）、工作记忆（d = -1.03）、言语学习（d = -1.02）、视觉学习（d = -0.91）和推理/问题解决（d = -0.67）。不存在显著的性别组间交互作用，但总体而言，女性在注意力/警觉性、言语学习和视觉学习方面比男性有优势，而男性在推理/问题解决方面比女性有优势。CMINDS可轻松用于评估神经精神疾病中的认知缺陷；特别是在可能最受益于电子数据采集的大规模研究中。
