可降解 Mg-Nd-Zn-Zr 合金的抗菌性能、生物相容性和耐腐蚀性增强。
Enhanced antibacterial properties, biocompatibility, and corrosion resistance of degradable Mg-Nd-Zn-Zr alloy.
机构信息
Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
出版信息
Biomaterials. 2015 Jun;53:211-20. doi: 10.1016/j.biomaterials.2015.02.096. Epub 2015 Mar 13.
Magnesium (Mg), a potential biodegradable material, has recently received increasing attention due to its unique antibacterial property. However, rapid corrosion in the physiological environment and potential toxicity limit clinical applications. In order to improve the corrosion resistance meanwhile not compromise the antibacterial activity, a novel Mg alloy, Mg-Nd-Zn-Zr (Hereafter, denoted as JDBM), is fabricated by alloying with neodymium (Nd), zinc (Zn), zirconium (Zr). pH value, Mg ion concentration, corrosion rate and electrochemical test show that the corrosion resistance of JDBM is enhanced. A systematic investigation of the in vitro and in vivo antibacterial capability of JDBM is performed. The results of microbiological counting, CLSM, SEM in vitro, and microbiological cultures, histopathology in vivo consistently show JDBM enhanced the antibacterial activity. In addition, the significantly improved cytocompatibility is observed from JDBM. The results suggest that JDBM effectively enhances the corrosion resistance, biocompatibility and antimicrobial properties of Mg by alloying with the proper amount of Zn, Zr and Nd.
镁（Mg）是一种具有潜在生物降解性的材料，由于其独特的抗菌性能，最近受到了越来越多的关注。然而，在生理环境中快速腐蚀和潜在毒性限制了其临床应用。为了提高耐腐蚀性，同时又不影响抗菌活性，我们通过添加钕（Nd）、锌（Zn）和锆（Zr）等元素制备了一种新型镁合金，即 Mg-Nd-Zn-Zr（简称 JDBM）。pH 值、Mg 离子浓度、腐蚀速率和电化学测试表明 JDBM 的耐腐蚀性得到了提高。我们对 JDBM 的体外和体内抗菌能力进行了系统的研究。体外微生物计数、CLSM、SEM 和体内微生物培养、组织病理学的结果一致表明 JDBM 增强了抗菌活性。此外，我们还观察到 JDBM 的细胞相容性显著提高。结果表明，通过适量添加 Zn、Zr 和 Nd，JDBM 有效地提高了镁的耐腐蚀性、生物相容性和抗菌性能。
Zotero 插件