Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum »Carl Gustav Carus« Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
Biomaterials. 2015;53:634-45. doi: 10.1016/j.biomaterials.2015.02.114. Epub 2015 Mar 24.
Currently, histological techniques are used to analyse implant-tissue-interactions. However, these methods are destructive and time-consuming. Furthermore, they require a large number of animals as longitudinal observations in one individual are not possible. The evaluation by non-destructive imaging techniques provides the opportunity to study the osseous integration with a reduced number of animals and a decreased biological variability. The present study examined the suitability of magnetic resonance imaging (MRI) to assess peri-implant bone formation exemplarily for a dental implant in a minipig model. Due to its compatibility to MR imaging polyetheretherketone (PEEK) coated with a thin layer of titanium was applied as implant material. Osseointegration was analysed within different peri-implant regions quantifying bone volume density and soft tissue content, which were assessed by MRI and histology, likewise. It could be proven that the examined regions showed differences in bone formation; the region adjacent to the implant apex turned out to be the most dynamic. Both methods led to comparable results with no significant differences regarding to the assessed parameters. Moreover, it was demonstrated that titanium coated PEEK showed a sufficient osseointegration and MRI provides a promising application in monitoring bone formation.
目前，组织学技术被用于分析种植体-组织相互作用。然而，这些方法具有破坏性且耗时，此外，它们需要大量动物，因为在一个个体中进行纵向观察是不可能的。非破坏性成像技术的评估提供了一个机会，可以用较少的动物和较少的生物学变异性来研究骨整合。本研究探讨了磁共振成像（MRI）评估种植体周围骨形成的适用性，以小型猪模型中的牙科种植体为例。由于其与磁共振成像的兼容性，聚醚醚酮（PEEK）涂有一层薄薄的钛被用作植入物材料。通过 MRI 和组织学同样评估了不同种植体周围区域的骨整合，定量分析了骨体积密度和软组织含量。可以证明，所检查的区域在骨形成方面存在差异；与植入物根尖相邻的区域被证明是最活跃的。两种方法都得到了可比的结果，在评估参数方面没有显著差异。此外，还证明了涂有钛的 PEEK 表现出了足够的骨整合，并且 MRI 为监测骨形成提供了一种很有前景的应用。
