Tambasco Nicola, Nigro Pasquale, Romoli Michele, Simoni Simone, Parnetti Lucilla, Calabresi Paolo
Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy.
Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy.
J Neurol Sci. 2015;353(1-2):1-8. doi: 10.1016/j.jns.2015.03.025. Epub 2015 Mar 28.
Magnetic resonance imaging is the most used technique of neuroimaging. Using recent advances in magnetic resonance application it is possible to investigate several changes in neurodegenerative disease. Among different techniques, magnetization-transfer imaging (MTI), a magnetic resonance acquisition protocol assessing the magnetization exchange between protons bound to water and those bound to macromolecules, is able to identify microstructural brain tissue changes peculiar of neurodegenerative diseases. This review provides a report on the MTI technique and its use in the dementia disorders, Huntington's disease and parkinsonisms, comprehensive of the predictive values of MTI in the identification of early-phase disease.
磁共振成像是神经成像中使用最广泛的技术。利用磁共振应用的最新进展，可以研究神经退行性疾病的多种变化。在不同技术中，磁化传递成像（MTI）是一种磁共振采集协议，用于评估与水结合的质子和与大分子结合的质子之间的磁化交换，能够识别神经退行性疾病特有的脑组织结构微观变化。本综述提供了关于MTI技术及其在痴呆症、亨廷顿舞蹈症和帕金森症中的应用的报告，全面介绍了MTI在早期疾病识别中的预测价值。
