3特斯拉下人类脑老化的酰胺质子转移加权磁共振成像
Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.
作者信息
Zhang Zewen, Zhang Caiqing, Yao Jian, Gao Fei, Gong Tao, Jiang Shanshan, Chen Weibo, Zhou Jinyuan, Wang Guangbin
机构信息
Department of MR, Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China.
Division of MR Research, Department of Radiology, Johns Hopkins University, Maryland, USA.
出版信息
Quant Imaging Med Surg. 2020 Mar;10(3):727-742. doi: 10.21037/qims.2020.02.22.
BACKGROUND
Amide proton transfer-weighted (APTw) imaging has been revealed to hold great potential in the diagnosis of several brain diseases. The purpose of this proof-of-concept study was to evaluate the feasibility and value of APTw magnetic resonance imaging (MRI) in characterizing normal brain aging.
METHODS
A total of 106 healthy subjects were recruited and scanned at 3.0 Tesla, with APTw and conventional magnetization transfer (MT) sequences. Quantitative image analyses were performed in 12 regions of interest (ROIs) for each subject. The APTw or MT ratio (MTR) signal differences among five age groups (young, mature, middle-aged, young-old, and middle-old) were assessed using the one-way analysis of variance, with the Benjamini-Hochberg correction for multiple comparisons. The relationship between APTw and MTR signals and the age dependencies of APTw and MTR signals were assessed using the Pearson correlation and non-linear regression.
RESULTS
There were no significant differences between the APTw or MTR values for males and females in any of the 12 ROIs analyzed. Among the five age groups, there were significant differences in the three white matter regions in the temporal, occipital, and frontal lobes. Overall, the mean APTw values in the older group were higher than those in the younger group. Positive correlations were observed in relation to age in most brain regions, including four with significant positive correlations (r=0.2065-0.4182) and five with increasing trends. As a comparison, the mean MTR values did not appear to be significantly different among the five age groups. In addition, the mean APTw and MTR values revealed significant positive correlations in 10 ROIs (r=0.2214-0.7269) and a significant negative correlation in one ROI (entorhinal cortex, r=-0.2141).
CONCLUSIONS
Our early results show that the APTw signal can be used as a promising and complementary imaging biomarker with which normal brain aging can be evaluated at the molecular level.
背景
已发现酰胺质子转移加权（APTw）成像在多种脑部疾病的诊断中具有巨大潜力。本概念验证研究的目的是评估APTw磁共振成像（MRI）在表征正常脑老化方面的可行性和价值。
方法
共招募了106名健康受试者，并在3.0特斯拉下进行扫描，采用APTw和传统磁化传递（MT）序列。对每个受试者的12个感兴趣区域（ROI）进行定量图像分析。使用单因素方差分析评估五个年龄组（青年、成熟、中年、年轻老年和中年老年）之间的APTw或MT比率（MTR）信号差异，并采用Benjamini-Hochberg校正进行多重比较。使用Pearson相关性和非线性回归评估APTw和MTR信号之间的关系以及APTw和MTR信号的年龄依赖性。
结果
在分析的12个ROI中的任何一个中，男性和女性的APTw或MTR值均无显著差异。在五个年龄组中，颞叶、枕叶和额叶的三个白质区域存在显著差异。总体而言，老年组的平均APTw值高于年轻组。在大多数脑区观察到与年龄的正相关，包括四个具有显著正相关（r = 0.2065 - 0.4182）和五个具有上升趋势的区域。作为比较，五个年龄组之间的平均MTR值似乎没有显著差异。此外，平均APTw和MTR值在10个ROI中显示出显著正相关（r = 0.2214 - 0.7269），在一个ROI（内嗅皮质，r = -0.2141）中显示出显著负相关。
结论
我们的早期结果表明，APTw信号可作为一种有前景的补充性成像生物标志物，用于在分子水平评估正常脑老化。
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