Forsyth Institute, Cambridge, MA 02142, USA; Harvard University, Cambridge, MA 02138, USA.
State University of New York at Buffalo, Buffalo, NY 14226, USA.
Trends Endocrinol Metab. 2015 Jun;26(6):315-21. doi: 10.1016/j.tem.2015.03.001. Epub 2015 Apr 16.
Oral infections are the most common diseases of mankind. Numerous reports have implicated oral infections, particularly periodontitis, as a risk factor for atherosclerotic cardiovascular disease (CVD). In this review we examine the epidemiology and biologic plausibility of this association with an emphasis on oral bacteria and inflammation. Longitudinal studies of incident cardiovascular events clearly show excess risk for CVD in individuals with periodontitis. It is likely that systemic exposure to oral bacteria impacts upon the initiation and progression of CVD through triggering of inflammatory processes. Given the high prevalence of periodontitis, any risk attributable to future CVD is important to public health. Unraveling the role of the oral microbiome in CVD will lead to new preventive and treatment approaches.
口腔感染是人类最常见的疾病。大量报告表明，口腔感染，特别是牙周炎，是动脉粥样硬化性心血管疾病（CVD）的一个危险因素。在这篇综述中，我们研究了这种关联的流行病学和生物学可能性，重点关注口腔细菌和炎症。关于心血管事件的纵向研究清楚地表明，牙周炎患者患 CVD 的风险增加。口腔细菌的全身暴露可能通过引发炎症过程而影响 CVD 的发生和发展。鉴于牙周炎的高患病率，任何归因于未来 CVD 的风险对公共健康都很重要。揭示口腔微生物组在 CVD 中的作用将带来新的预防和治疗方法。
