Martos Renáta, Márton Ildikó
Debreceni Egyetem Orvos és Egészségtudományi Centrum Fogorvostudományi Kar, Debrecen.
Fogorv Sz. 2008 Jun;101(3):101-5.
The potential role of periodontal disease, gingivitis and other dental infections as a possible chronic source of infection and inflammation represents a continuous challenge to the host organism. The high number of oral pathogens, lipopolysaccharides and soluble mediators are related to the pathogenesis of local inflammation and the initiation of systemic inflammation process, which may impair systemic health. In the last decades, studies suggested that there could be a connection between the local oral infections and several systemic conditions such as diabetes, cardiovascular disease, low birth weight and chronic obstructive pulmonary disease. Cardiovascular disease is the number one cause of death in the last century. The primary contributing factor in the majority of cardiovascular diseases is atherosclerosis. The role of infection is believed to provide a critical inflammatory stimulus that contributes to atherogenesis. The present review is a short summary of studies of the last years about the possible pathogenic role of local oral infections as a contributing factor in the initiation and progression of cardiovascular disease.
牙周病、牙龈炎及其他牙齿感染作为潜在的慢性感染源和炎症源，对宿主生物体构成持续挑战。大量口腔病原体、脂多糖和可溶性介质与局部炎症的发病机制以及全身炎症过程的启动有关，这可能损害全身健康。在过去几十年中，研究表明局部口腔感染与多种全身疾病之间可能存在联系，如糖尿病、心血管疾病、低出生体重和慢性阻塞性肺疾病。心血管疾病是上个世纪的头号死因。大多数心血管疾病的主要促成因素是动脉粥样硬化。感染被认为提供了一种关键的炎症刺激，有助于动脉粥样硬化的发生。本综述简要总结了近年来关于局部口腔感染作为心血管疾病发生和发展的促成因素可能的致病作用的研究。
