Szalayova Gabriela, James Ted A, Rincon Mercedes
Department of Surgery, Western Connecticut Health Network, 24 Hospital Avenue, Danbury, CT, 06810, USA.
Breast Cancer Res Treat. 2015 Jun;151(2):235-8. doi: 10.1007/s10549-015-3392-5. Epub 2015 Apr 19.
Breast cancer remains the second leading cancer-related death in women in the United States. Despite improvements in early detection, prevention, and treatment, the mortality rate in breast cancer remains high secondary to the potential for cancer recurrence and the development of metastasis. To minimize breast cancer-related morbidity and mortality, understanding the factors leading to an increased risk of metastasis and developing clinical interventions that reduce this risk is essential. While the association between chronic inflammation and cancer progression is well documented in the literature, the role of acute inflammation and its impact on tumor proliferation and metastasis is less well understood. Here, we will review recently published preclinical studies in mouse models indicating that acute inflammation caused by clinical interventions plays an important role in the risk of peripheral metastases. In addition, we will address the potential impact that these findings may have on the clinical management of breast cancer.
乳腺癌仍是美国女性癌症相关死亡的第二大原因。尽管在早期检测、预防和治疗方面有所改善，但由于癌症复发和转移的可能性，乳腺癌的死亡率仍然很高。为了将乳腺癌相关的发病率和死亡率降至最低，了解导致转移风险增加的因素并开发降低这种风险的临床干预措施至关重要。虽然慢性炎症与癌症进展之间的关联在文献中有充分记载，但急性炎症的作用及其对肿瘤增殖和转移的影响却鲜为人知。在这里，我们将回顾最近发表的在小鼠模型中的临床前研究，这些研究表明临床干预引起的急性炎症在周围转移风险中起重要作用。此外，我们将探讨这些发现可能对乳腺癌临床管理产生的潜在影响。
