Polat M, Senol T, Ozkaya E, Ogurlu Pakay G, Cikman M S, Konukcu B, Ozten M A, Karateke A
Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children's Health Training and Research Hospital, Opr. Dr. Burhanettin Üstünel Cad. No:10, Üsküdar/Istanbul, Turkey.
Clin Transl Oncol. 2016 May;18(5):457-63. doi: 10.1007/s12094-015-1387-7. Epub 2015 Aug 20.
The aim of this study was to assess the predictive value of neutrophil/lymphocyte and platelet/lymphocyte ratios for borderline, malignant ovarian tumors, and borderline cases with microinvasion.
Totally 275 women with sonographically detected ovarian tumor were enrolled for this study. All subjects underwent gynecological surgery via endoscopic or conventional approach and ovarian masses were all evaluated histopathologically by the same pathologist. All study population was divided into three groups as group with borderline tumors, benign tumors, or malignant tumors according to the histopathological diagnosis. Just before surgical intervention, a blood sample was obtained from each participant to analyze CA125 level, neutrophil, platelet, and lymphocyte count.
Neutrophil/lymphocyte ratio (AUC = 0.604, P = 0.02) was a significant predictor for malignant cases. Optimal cutoff value for the neutrophil/lymphocyte ratio was found to be 2.47 with 63.4% sensitivity and 63.5% specificity for malignancy prediction. Odds ratio of high neutrophil/lymphocyte ratio for malignancy risk was 2.5 (95% CI 1.3-4.8, P = 0.004). Platelet/lymphocyte ratio (AUC = 0.621, P = 0.007) was a significant predictor for malignant cases. Platelet/lymphocyte ratio (AUC = 0.568, P = 0.05) was also predictive for cases without a benign mass. Optimal cutoff value for the platelet/lymphocyte ratio was found to be 144.3 with 54% sensitivity and 59% specificity for malignancy prediction. Odds ratio of high platelet/lymphocyte ratio for malignancy risk was 2.1 (95% CI 1.1-3.8, P = 0.02).
Neutrophil/lymphocyte and platelet/lymphocyte ratios are predictors for malignant ovarian tumors but not borderline tumors even in case of microinvasion.
本研究旨在评估中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值对交界性、恶性卵巢肿瘤以及伴有微浸润的交界性病例的预测价值。
本研究共纳入275例经超声检查发现卵巢肿瘤的女性。所有受试者均通过内镜或传统方法接受妇科手术，卵巢肿块均由同一位病理学家进行组织病理学评估。根据组织病理学诊断，将所有研究人群分为交界性肿瘤组、良性肿瘤组或恶性肿瘤组。在手术干预前，从每位参与者采集血样，分析CA125水平、中性粒细胞、血小板和淋巴细胞计数。
中性粒细胞/淋巴细胞比值（AUC = 0.604，P = 0.02）是恶性病例的显著预测指标。中性粒细胞/淋巴细胞比值的最佳截断值为2.47，预测恶性肿瘤的敏感性为63.4%，特异性为63.5%。高中性粒细胞/淋巴细胞比值的恶性风险比值比为2.5（95%CI 1.3 - 4.8，P = 0.004）。血小板/淋巴细胞比值（AUC = 0.621，P = 0.007）是恶性病例的显著预测指标。血小板/淋巴细胞比值（AUC = 0.568，P = ）对无良性肿块的病例也具有预测性。血小板/淋巴细胞比值的最佳截断值为144.3，预测恶性肿瘤的敏感性为54%，特异性为59%。高血小板/淋巴细胞比值的恶性风险比值比为2.1（95%CI 1.1 - 3.8，P = 0.02）。
中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值是恶性卵巢肿瘤的预测指标，但不是交界性肿瘤的预测指标，即使在伴有微浸润的情况下也是如此。
