IFB Adiposity Diseases, University of Leipzig, Liebigstraße 21, 04103, Leipzig, Germany,
Genes Nutr. 2015 Jan;10(1):449. doi: 10.1007/s12263-014-0449-8. Epub 2014 Dec 27.
The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eating. Here, we tested the hypothesis that (1) adiponectin serum levels correlate with human eating behavior factors and (2) that genetic variants of the ADIPOQ locus influence both serum levels and eating behavior. We analyzed 11 SNPs within ADIPOQ and in the 5' UTR and measured serum adiponectin levels in 1,036 individuals from the German Sorbs population. The German version of the three-factor eating questionnaire (FEV) was completed by 548 Sorbs. For replication purposes, we included an independent replication cohort from Germany (N = 350). In the Sorbs, we observed positive correlations of restraint with adiponectin serum levels (P = 0.001; r = 0.148) which, however, did not withstand adjustment for covariates (P = 0.083; r = 0.077). In addition, four SNPs were nominally associated with serum adiponectin levels (all P < 0.05). Of these, two variants (rs3774261; rs1501229, all P < 0.05) were also related to disinhibition. Furthermore, three variants were exclusively associated with hunger (rs2036373, P = 0.049) and disinhibition (rs822396; rs864265, all P < 0.05). However, none of these associations withstood Bonferroni corrections for multiple testing (all P > 9.3 × 10(-4)). In our replication cohort, we observed similar effect directions at rs1501229 for disinhibition and hunger. A meta-analysis resulted in nominal statistical significance P = 0.036 (Z score 2.086) and P = 0.017 (Z score 2.366), respectively. Given the observed relationship of the SNPs with adiponectin levels and eating behavior, our data support a potential role of adiponectin in human eating behavior. Whether the relationship with eating behavior is mediated by the effects of circulating adiponectin warrants further investigations.
脂联素的有益作用及其与 BMI 的负相关关系已得到很好的描述。脂联素血清水平在神经性厌食症、神经性贪食症或暴食症等饮食失调中发生改变。在这里，我们检验了以下假设：（1）脂联素血清水平与人类饮食行为因素相关；（2）ADIPOQ 基因座的遗传变异既影响血清水平又影响饮食行为。我们分析了德国索布人种群 1036 个人中的 11 个 ADIPOQ 内和 5'UTR 内的 SNP，并测量了血清脂联素水平。548 名索布人完成了德国版三因素饮食问卷（FEV）。为了进行复制目的，我们纳入了德国的一个独立复制队列（N=350）。在索布人中，我们观察到抑制与脂联素血清水平呈正相关（P=0.001；r=0.148），但在调整协变量后无统计学意义（P=0.083；r=0.077）。此外，有四个 SNP 与血清脂联素水平呈名义相关（均 P<0.05）。其中，两个变体（rs3774261；rs1501229，均 P<0.05）也与去抑制有关。此外，三个变体仅与饥饿（rs2036373，P=0.049）和去抑制（rs822396；rs864265，均 P<0.05）有关。然而，这些与多变量测试的 Bonferroni 校正相比，均无统计学意义（均 P>9.3×10(-4)）。在我们的复制队列中，我们观察到 rs1501229 与去抑制和饥饿的相似效应方向。Meta 分析结果分别为名义统计学意义 P=0.036（Z 分数 2.086）和 P=0.017（Z 分数 2.366）。鉴于观察到的 SNP 与脂联素水平和饮食行为的关系，我们的数据支持脂联素在人类饮食行为中的潜在作用。饮食行为的这种关系是否由循环脂联素的作用介导，还需要进一步研究。
