在接受治疗的高血压患者中，动脉僵硬度与血压随时间升高有关。
Arterial stiffness is associated with increase in blood pressure over time in treated hypertensives.
作者信息
Coutinho Thais, Bailey Kent R, Turner Stephen T, Kullo Iftikhar J
机构信息
Department of Medicine, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
出版信息
J Am Soc Hypertens. 2014 Jun;8(6):414-21. doi: 10.1016/j.jash.2014.03.330. Epub 2014 Apr 4.
Arterial stiffness is associated with incident hypertension. We hypothesized that measures of arterial stiffness would predict increases in systolic (SBP), mean (MAP), and pulse pressure (PP) over time in treated hypertensives. Blood pressure (BP) was measured a mean of 8.5 ± 0.9 years apart in 414 non-Hispanic white hypertensives (mean age, 60 ± 8 years; 55% women). The average of three supine right brachial BPs was recorded. Measures of arterial stiffness, including carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and central pulse pressure (CPP), were obtained at baseline by applanation tonometry. We performed stepwise multivariable linear regression analyses adjusting for potential confounders to assess the associations of arterial stiffness parameters with BP changes over time. SBP, MAP, and PP increased in 80% of participants. After adjustment for covariates listed, cfPWV (m/s) was associated with increases in SBP (β ± standard error [SE], 0.71 ± 0.31) and PP (β ± SE, 1.09 ± 0.27); AIx (%) was associated with increases in SBP (β ± SE, 0.23 ± 0.10) and MAP (β ± SE, 0.27 ± 0.07); and CPP (mmHg) was associated with increases in SBP (β ± SE, 0.44 ± 0.07), MAP (β ± SE, 0.24 ± 0.05), and PP (β ± SE, 0.42 ± 0.06) over time (P ≤ .02 for each). In conclusion, arterial stiffness measures were associated with longitudinal increases in SBP, MAP, and PP in treated hypertensives.
动脉僵硬度与高血压发病相关。我们假设，在接受治疗的高血压患者中，动脉僵硬度指标可预测收缩压（SBP）、平均动脉压（MAP）和脉压（PP）随时间的升高情况。在414名非西班牙裔白人高血压患者（平均年龄60±8岁；55%为女性）中，平均每隔8.5±0.9年测量一次血压（BP）。记录右侧肱动脉三个仰卧位血压的平均值。通过压平式眼压计在基线时获取包括颈股脉搏波速度（cfPWV）、主动脉增强指数（AIx）和中心脉压（CPP）在内的动脉僵硬度指标。我们进行了逐步多变量线性回归分析，对潜在混杂因素进行校正，以评估动脉僵硬度参数与血压随时间变化的关联。80%的参与者的SBP、MAP和PP升高。在校正列出的协变量后，cfPWV（m/s）与SBP升高（β±标准误[SE]，0.71±0.31）和PP升高（β±SE，1.09±0.27）相关；AIx（%）与SBP升高（β±SE，0.23±0.10）和MAP升高（β±SE，0.27±0.07）相关；CPP（mmHg）与SBP升高（β±SE，0.44±0.07）、MAP升高（β±SE，0.24±0.05）和PP升高（β±SE，0.42±0.06）随时间相关（每项P≤0.02）。总之，在接受治疗的高血压患者中，动脉僵硬度指标与SBP、MAP和PP的纵向升高相关。
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