Lazaridis Christos, Maas Andrew I R, Souter Michael J, Martin Renee H, Chesnut Randal M, DeSantis Stacia M, Sung Gene, Leroux Peter D, Suarez Jose I
Division of Neurocritical Care and Vascular Neurology, Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, MS: NB320, Houston, TX, 77030, USA,
Neurocrit Care. 2015 Jun;22(3):378-84. doi: 10.1007/s12028-015-0135-8.
Neurocritical care involves the care of highly complex patients with combinations of physiologic derangements in the brain and in extracranial organs. The level of evidence underpinning treatment recommendations remains low due to a multitude of reasons including an incomplete understanding of the involved physiology; lack of good quality, prospective, standardized data; and the limited success of conventional randomized controlled trials. Comparative effectiveness research can provide alternative perspectives and methods to enhance knowledge and evidence within the field of neurocritical care; these include large international collaborations for generation and maintenance of high quality data, statistical methods that incorporate heterogeneity and individualize outcome prediction, and finally advanced bioinformatics that integrate large amounts of variable-source data into patient-specific phenotypes and trajectories.
神经重症监护涉及对大脑和颅外器官存在生理紊乱组合的高度复杂患者的护理。由于多种原因，包括对所涉及生理机制的不完全理解、缺乏高质量、前瞻性、标准化的数据以及传统随机对照试验的有限成功，支撑治疗建议的证据水平仍然较低。比较效果研究可以提供替代的观点和方法，以增强神经重症监护领域的知识和证据；这些包括用于生成和维护高质量数据的大型国际合作、纳入异质性并个性化结果预测的统计方法，以及最终将大量可变来源数据整合到患者特异性表型和病程中的先进生物信息学。
