Soisson A P, Berchuck A, Lessey B A, Soper J T, Clarke-Pearson D L, McCarty K S, Bast R C
Department of Obstetrics and Gynecology, Duke University, Durham, NC.
Am J Obstet Gynecol. 1989 Nov;161(5):1258-63. doi: 10.1016/0002-9378(89)90678-9.
TAG-72 is a tumor-associated antigen that is expressed by secretory endometrium and most endometrial adenocarcinomas. We used immunohistochemical techniques to quantitate expression of TAG-72, estrogen receptor, and progesterone receptor in 21 normal endometria and 44 endometrial adenocarcinomas. In normal cycling endometrial glands, TAG-72 expression was related inversely to expression of receptors for estrogen and progesterone. This suggests that TAG-72 expression in normal endometrium may be hormonally regulated. Ninety-one percent of endometrial adenocarcinomas expressed immunohistochemically detectable TAG-72. The magnitude of TAG-72 expression did not correlate with other known prognostic factors in endometrial cancer such as histologic grade, depth of myometrial invasion, surgical stage, or steroid receptor status. The production of TAG-72 by most endometrial adenocarcinomas may represent nonspecific expression by cells that have dedifferentiated.
TAG-72是一种肿瘤相关抗原，由分泌期子宫内膜和大多数子宫内膜腺癌表达。我们采用免疫组化技术对21例正常子宫内膜和44例子宫内膜腺癌中TAG-72、雌激素受体和孕激素受体的表达进行定量分析。在正常周期性子宫内膜腺体中，TAG-72的表达与雌激素和孕激素受体的表达呈负相关。这表明正常子宫内膜中TAG-72的表达可能受激素调节。91%的子宫内膜腺癌免疫组化可检测到TAG-72表达。TAG-72表达的程度与子宫内膜癌其他已知的预后因素如组织学分级、肌层浸润深度、手术分期或类固醇受体状态无关。大多数子宫内膜腺癌产生TAG-72可能代表去分化细胞的非特异性表达。
