Hughes Timothy M, Craft Suzanne, Lopez Oscar L
Department of Internal Medicine, Division of Gerontology & Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1207, USA.
Neurodegener Dis Manag. 2015;5(2):121-35. doi: 10.2217/nmt.14.53.
Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia through its associations with cerebral small vessel disease, stroke, β-amyloid deposition, brain atrophy and cognitive impairment. Arterial stiffness directly relates the detrimental effects of hypertension on peripheral organs with dire consequences for the extensive microvasculature structure of the kidneys and brain. In this review, we discuss the evidence linking arterial stiffness, hypertension and brain structural abnormalities in older adults. In particular, we discuss the potential mechanisms linking arterial stiffness to brain β-amyloid deposition and dementia and potential therapeutic strategies to prevent hypertension's adverse effects on the brain.
动脉僵硬度正逐渐成为脑衰老和痴呆的重要风险标志物，因为它与脑小血管疾病、中风、β-淀粉样蛋白沉积、脑萎缩和认知障碍有关。动脉僵硬度直接将高血压对周围器官的有害影响与对肾脏和大脑广泛微血管结构的严重后果联系起来。在本综述中，我们讨论了老年人动脉僵硬度、高血压与脑结构异常之间联系的证据。特别是，我们讨论了将动脉僵硬度与脑β-淀粉样蛋白沉积和痴呆联系起来的潜在机制，以及预防高血压对大脑产生不利影响的潜在治疗策略。
