Fernie Bruce A, Murphy Gabrielle, Wells Adrian, Nikčević Ana V, Spada Marcantonio M
King's College London,Institute of Psychiatry,Psychology and Neuroscience, and Cascaid,South London and Maudsley NHS Foundation Trust,UK.
Royal Free Hampstead NHS Foundation Trust,London,UK.
Behav Cogn Psychother. 2016 Jul;44(4):397-409. doi: 10.1017/S135246581500017X. Epub 2015 Apr 21.
Studies have reported that Cognitive Behavioural Therapy (CBT) and Graded Exercise Therapy (GET) are effective treatments for Chronic Fatigue Syndrome (CFS).
One hundred and seventy-one patients undertook a course of either CBT (n = 116) or GET (n = 55) and were assessed on a variety of self-report measures at pre- and posttreatment and follow-up.
In this paper we present analyses on treatment outcomes for CBT and GET in routine clinical practice and evaluate whether changes on subscales of the Metacognitions Questionnaire-30 (MCQ-30) predict fatigue severity independently of changes in other covariates, and across the two treatment modalities.
Both CBT and GET were equally effective at decreasing fatigue, anxiety, and depression, and at increasing physical functioning. Changes on the subscales of the MCQ-30 were also found to have a significant effect on fatigue severity independently of changes in other covariates and across treatment modalities.
The findings from the current study suggest that CFS treatment protocols for CBT and GET, based on those from the PACE trial, achieve similar to poorer outcomes in routine clinical practice as in a RCT.
研究报告称，认知行为疗法（CBT）和分级运动疗法（GET）是治疗慢性疲劳综合征（CFS）的有效方法。
171名患者接受了CBT（n = 116）或GET（n = 55）疗程，并在治疗前、治疗后和随访时通过多种自我报告测量方法进行评估。
在本文中，我们对常规临床实践中CBT和GET的治疗结果进行分析，并评估元认知问卷30（MCQ - 30）子量表的变化是否能独立于其他协变量的变化以及在两种治疗方式中预测疲劳严重程度。
CBT和GET在减轻疲劳、焦虑和抑郁以及提高身体机能方面同样有效。还发现MCQ - 30子量表的变化独立于其他协变量的变化以及在不同治疗方式中对疲劳严重程度有显著影响。
当前研究结果表明，基于PACE试验的CBT和GET的CFS治疗方案，在常规临床实践中的效果与随机对照试验中的效果相似或更差。
