Deumer Undine-Sophie, Varesi Angelica, Floris Valentina, Savioli Gabriele, Mantovani Elisa, López-Carrasco Paulina, Rosati Gian Marco, Prasad Sakshi, Ricevuti Giovanni
Department of Biological Sciences, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.
Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
J Clin Med. 2021 Oct 19;10(20):4786. doi: 10.3390/jcm10204786.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic systemic disease that manifests via various symptoms such as chronic fatigue, post-exertional malaise, and cognitive impairment described as "brain fog". These symptoms often prevent patients from keeping up their pre-disease onset lifestyle, as extended periods of physical or mental activity become almost impossible. However, the disease presents heterogeneously with varying severity across patients. Therefore, consensus criteria have been designed to provide a diagnosis based on symptoms. To date, no biomarker-based tests or diagnoses are available, since the molecular changes observed also largely differ from patient to patient. In this review, we discuss the infectious, genetic, and hormonal components that may be involved in CFS pathogenesis, we scrutinize the role of gut microbiota in disease progression, we highlight the potential of non-coding RNA (ncRNA) for the development of diagnostic tools and briefly mention the possibility of SARS-CoV-2 infection causing CFS.
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种慢性全身性疾病，通过多种症状表现出来，如慢性疲劳、运动后不适以及被称为“脑雾”的认知障碍。这些症状常常使患者无法维持患病前的生活方式，因为长时间的体力或脑力活动几乎变得不可能。然而，该疾病在不同患者中表现出异质性，严重程度各不相同。因此，已制定了共识标准以根据症状进行诊断。迄今为止，尚无基于生物标志物的检测或诊断方法，因为观察到的分子变化在很大程度上也因患者而异。在本综述中，我们讨论了可能参与CFS发病机制的感染、遗传和激素成分，审视了肠道微生物群在疾病进展中的作用，强调了非编码RNA（ncRNA）在开发诊断工具方面的潜力，并简要提及了SARS-CoV-2感染导致CFS的可能性。
