Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Psychiatry Res. 2015 Jun 30;227(2-3):230-7. doi: 10.1016/j.psychres.2015.02.025. Epub 2015 Mar 31.
This longitudinal study examines to what extent different depressive and anxiety disorders and clinical characteristics are associated with subsequent weight change, while controlling for baseline weight, sociodemographics, health status, psychotropic medication use and (un)healthy lifestyle factors. Data are from a sample of 2447 respondents aged 18-65 years of the Netherlands Study of Depression and Anxiety (NESDA). Baseline depressive disorders and anxiety disorders were determined with the Composite International Diagnostic Interview (CIDI). Weight at baseline and after 2 years was measured and analyzed as continuous change score (mean change in weight 1kg) and in categories of significant weight loss (<1S.D. weight change equaling <4kg), weight maintenance and weight gain (>1S.D., >6kg). After full adjustment for covariates baseline comorbid anxiety and depressive disorder and baseline Major Depressive Disorder (MDD) were associated with significant 2-year weight gain. Both current and remitted MDD at baseline and a baseline dysthymia, but none of the anxiety disorders, were associated with significant weight loss. This longitudinal study confirms a U-curved link between depression and weight change over 2 years. Furthermore, a dose-response effect of depression severity on 2-year weight gain was found.
本纵向研究旨在探讨在控制基线体重、社会人口统计学特征、健康状况、精神药物使用和（不健康）生活方式因素的情况下，不同的抑郁和焦虑障碍及临床特征与随后的体重变化有何关联。数据来自荷兰抑郁和焦虑研究（NESDA）中年龄在 18-65 岁的 2447 名受访者的样本。基线抑郁障碍和焦虑障碍通过复合国际诊断访谈（CIDI）确定。基线和 2 年后的体重通过连续变化分数（体重变化的平均值 1kg）和显著体重减轻（<1S.D.体重变化<4kg）、体重维持和体重增加（>1S.D.，>6kg）的类别进行测量和分析。在对所有协变量进行充分调整后，基线共病焦虑和抑郁障碍以及基线重度抑郁症（MDD）与 2 年内显著体重增加相关。基线时的当前和缓解性 MDD 以及基线时的心境恶劣，但没有任何一种焦虑障碍，与显著的体重减轻相关。本纵向研究证实了抑郁与 2 年内体重变化之间存在 U 型关联。此外，还发现抑郁严重程度与 2 年内体重增加之间存在剂量反应关系。
