Bliddal M, Pottegård A, Kirkegaard H, Olsen J, Sørensen T I A, Nohr E A
Institute of Clinical Research, Research Unit of Gynaecology and Obstetrics University of Southern Denmark Odense Denmark; Department of Gynaecology and Obstetrics Odense University Hospital Odense Denmark; OPEN - Odense Patient data Explorative Network Odense University Hospital Odense Denmark.
Clinical Pharmacology, Department of Public Health University of Southern Denmark Odense Denmark.
Obes Sci Pract. 2016 Dec;2(4):415-425. doi: 10.1002/osp4.75. Epub 2016 Nov 9.
This study aimed to examine how weight and weight changes related to pregnancy were associated with depressive symptoms 11-16 years after childbirth.
We followed 16,998 first-time mothers from the Danish National Birth Cohort up till 16 years after birth and estimated associations between depressive symptoms and pre-pregnancy body mass index (BMI) (kg m), weight changes in different time periods, and BMI-adjusted waist circumference 7 years after birth (WC, cm). Depressive symptoms were estimated by the Center for Epidemiologic Studies Depression 10-item scale. Multiple logistic regression analyses were used to estimate odds ratios (OR) and 95% confidence intervals.
Compared with normal-weight, we found that underweight, overweight and obesity were associated with greater odds of depressive symptoms (1.29, 1.24 and 1.73, respectively). Compared with weight change ±1 BMI unit during the total follow-up period, greater odds for depressive symptoms were observed with weight loss (OR 1.14, 0.96-1.36) or gain of 2-2.99 kg m (OR 1.11, 0.92-1.33) or gain of ≥3 kg m (OR 1.68, 1.46-1.94). WC > 2.2 cm was associated with greater odds of depressive symptoms (OR 1.16, 0.99-1.36) than waist circumference as predicted by BMI.
Low and high pre-pregnancy BMI, weight changes and WC larger than predicted were associated with more depressive symptoms in midlife.
本研究旨在探讨孕期体重及体重变化与产后11至16年抑郁症状之间的关联。
我们对丹麦国家出生队列中的16998名初产妇进行了随访，直至产后16年，并估计了抑郁症状与孕前体重指数（BMI，kg/m²）、不同时间段的体重变化以及产后7年经BMI调整的腰围（WC，cm）之间的关联。抑郁症状通过流行病学研究中心抑郁10项量表进行评估。采用多元逻辑回归分析来估计比值比（OR）和95%置信区间。
与正常体重相比，我们发现体重过轻、超重和肥胖与抑郁症状的较高几率相关（分别为1.29、1.24和1.73）。与整个随访期间体重变化±1个BMI单位相比，体重减轻（OR 1.14，0.96 - 1.36）或增加2 - 2.99 kg/m²（OR 1.11，0.92 - 1.33）或增加≥3 kg/m²（OR 1.68，1.46 - 1.94）时，抑郁症状的几率更高。WC > 2.2 cm与抑郁症状的较高几率相关（OR 1.16，0.99 - 1.36），高于BMI预测的腰围。
孕前BMI过低或过高、体重变化以及大于预测值的WC与中年时期更多的抑郁症状相关。
