Saie Amir Ata, Ray Moumita, Mahmoudi Morteza, Rotello Vincent M
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Cancer Treat Res. 2015;166:245-73. doi: 10.1007/978-3-319-16555-4_11.
Intracellular delivery of functional proteins using nanoparticles can be a game-changing approach for cancer therapy. However, cytosolic release of functional protein is still a major challenge. In addition, formation of protein corona on the surface of the nanoparticles can also alter the behavior of the nanoparticles. Here, we will review recent strategies for protein delivery into the cell. Finally we will discuss the issue of protein corona formation in light of nanoparticle-protein interactions.
使用纳米颗粒进行功能性蛋白质的细胞内递送可能成为癌症治疗中改变游戏规则的方法。然而，功能性蛋白质的胞质释放仍然是一个重大挑战。此外，纳米颗粒表面蛋白质冠的形成也会改变纳米颗粒的行为。在此，我们将综述蛋白质递送进入细胞的最新策略。最后，我们将根据纳米颗粒与蛋白质的相互作用来讨论蛋白质冠形成的问题。
