Lam Robert, Ho Dean
Northwestern University, Robert R McCormick School of Engineering and Applied Science, Department of Mechanical Engineering, Evanston, IL 60208, USA.
Expert Opin Drug Deliv. 2009 Sep;6(9):883-95. doi: 10.1517/17425240903156382.
Owing to their exceptional biocompatibility and unique surface properties, nanodiamonds (NDs) are shown to be a progressively promising nanomaterial for drug delivery. In this article, NDs as a platform for a host of biomedical applications are described, with an emphasis on cancer therapy, ranging from systemic modalities to primary constituents within polymer hybrid microfilms. Experimental results and theoretical explanations of ND-drug dynamics are compared. Water-dispersion of previously insoluble therapeutics when complexed with NDs demonstrates great promise in expanding current drug delivery options. Various forms of incorporating NDs within microfilms as a localized drug release coating and implant are also discussed.
由于其卓越的生物相容性和独特的表面性质，纳米金刚石（NDs）被证明是一种在药物递送方面越来越有前景的纳米材料。在本文中，描述了NDs作为一系列生物医学应用的平台，重点是癌症治疗，从全身治疗方式到聚合物混合微膜中的主要成分。比较了ND-药物动力学的实验结果和理论解释。与NDs复合时，先前不溶性治疗药物的水分散体在扩展当前药物递送选择方面显示出巨大潜力。还讨论了将NDs以各种形式纳入微膜作为局部药物释放涂层和植入物的情况。
