纳米颗粒如何与癌细胞相互作用。

How nanoparticles interact with cancer cells.

作者信息

Syed Abdullah, Chan Warren C W

机构信息

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College St., 407, Toronto, ON, M5S 3G9, Canada.

出版信息

Cancer Treat Res. 2015;166:227-44. doi: 10.1007/978-3-319-16555-4_10.

DOI:10.1007/978-3-319-16555-4_10

PMID:25895871

Abstract

There are currently no nanoparticle formulations that optimally target diseased cells in the body. A small percentage of nanoparticles reach these cells and most accumulate in cells of the mononuclear phagocytic system. This chapter explores the interactions between nanoparticles and cells that may explain the causes for off-target accumulation of nanoparticles. A greater understanding of the nanoparticle-cellular interactions will lead to improvements in particle design for improved therapeutic outcome.

摘要

目前尚无能够最佳靶向体内病变细胞的纳米颗粒制剂。只有一小部分纳米颗粒能够到达这些细胞，而大多数纳米颗粒会在单核吞噬系统的细胞中蓄积。本章探讨了纳米颗粒与细胞之间的相互作用，这些相互作用可能解释了纳米颗粒非靶向蓄积的原因。对纳米颗粒与细胞相互作用的更深入了解将有助于改进颗粒设计，从而提高治疗效果。