Invernizzi M, Carda S, Rizzi M, Grana E, Squarzanti D F, Cisari C, Molinari C, Renò F
1] Physical and Rehabilitation Medicine, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy [2] Società Italiana per lo Studio delle Disabilità Muscolo-Scheletriche-SISDIM, Novara, Italy.
Department of Neurorehabilitation and Neuropsychology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Spinal Cord. 2015 Aug;53(8):615-20. doi: 10.1038/sc.2015.61. Epub 2015 Apr 21.
Case-control study.
To assess serum myostatin levels, bone mineral density (BMD), appendicular skeletal muscle mass (ASMM) and serum sclerostin levels in chronic spinal cord injured (SCI) patients and healthy controls.
SCI centre in Italy.
Blood samples, whole-body bioelectrical impedance analysis and BMD measurement with the ultrasound technique at the calcaneus level were taken from patients suffering from chronic SCI (both motor complete and incomplete) and healthy control subjects.
A total of 28 SCI patients and 15 healthy controls were enrolled. Serum myostatin levels were statistically higher (P<0.01) in SCI patients compared with healthy controls. Similar results were found comparing both the motor complete and the motor incomplete SCI subgroups to healthy controls. Serum sclerostin was significantly higher in patients with SCI compared with healthy controls (P<0.01). BMD, stiffness and mean T-score values in SCI patients were significantly lower than those in healthy controls. Serum myostatin concentrations in the motor complete SCI subgroups correlated only with serum sclerostin levels (r(2)=0.42; P=0.001) and ASMM (r(2)=0.70; P=0.002) but not in healthy controls.
Serum myostatin and serum sclerostin are significantly higher in chronic SCI patients compared with healthy controls. They are potential biomarkers of muscle and bone modifications after SCI. This is the first study reporting an increase in serum myostatin in patients suffering from chronic SCI and a correlation with ASMM.
病例对照研究。
评估慢性脊髓损伤（SCI）患者和健康对照者的血清肌生成抑制素水平、骨密度（BMD）、四肢骨骼肌质量（ASMM）和血清硬化蛋白水平。
意大利的脊髓损伤中心。
采集慢性SCI患者（运动完全性和不完全性）和健康对照者的血样、进行全身生物电阻抗分析，并采用超声技术测量跟骨水平的骨密度。
共纳入28例SCI患者和15名健康对照者。与健康对照者相比，SCI患者的血清肌生成抑制素水平在统计学上显著更高（P<0.01）。运动完全性和运动不完全性SCI亚组与健康对照者相比也有类似结果。与健康对照者相比，SCI患者的血清硬化蛋白显著更高（P<0.01）。SCI患者的骨密度、硬度和平均T值显著低于健康对照者。运动完全性SCI亚组的血清肌生成抑制素浓度仅与血清硬化蛋白水平（r(2)=0.42；P=0.001）和ASMM（r(2)=0.70；P=0.002）相关，而在健康对照者中无此相关性。
与健康对照者相比，慢性SCI患者的血清肌生成抑制素和血清硬化蛋白显著更高。它们是SCI后肌肉和骨骼改变的潜在生物标志物。这是第一项报道慢性SCI患者血清肌生成抑制素升高及其与ASMM相关性的研究。
