Zhao Hong, Zou Liwei, Geng Xiaoping, Zheng Suisheng
Department of Radiology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, 230000, China.
Department of Surgery, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, 230000, China.
Eur J Med Res. 2015 Apr 21;20(1):49. doi: 10.1186/s40001-015-0140-6.
The aim of this study is to compare X-ray mammography (MG) and ultrasonography (US) in the diagnosis of breast diseases in Chinese women.
We retrospectively analyzed X-ray mammograms of 274 patients with US and surgical/pathological results of breast diseases diagnosed at The Second Affiliated Hospital of Anhui Medical University (Hefei, China) between March 2011 and November 2014. The MG and US data were compared to surgical records using the results from post-surgical pathological examinations as the gold standard.
The overall sensitivity, specificity, accuracy, false-positive, false-negative, positive predictive value, and negative predictive value for the detection of breast cancer were 88.5%, 57.9%, 73.7%, 42.1%, 11.5%, 69.2%, and 82.5%, respectively, for MG and 95.9%, 66.7%, 81.8%, 33.3%, 4.1%, 75.5%, and 93.8%, respectively, for US. Of the 274 cases, lesion size by MG agreed with surgery in 133 (48.5%) patients compared with 216 (78.8%) by US (P < 0.01). Lesion location by MG agreed with surgery in 146 (53.3%) patients compared with 257 (93.8%) by US (P < 0.01). These values were then stratified according to age, menstrual status, breast density, and breast volume, and the agreement rates of MG with surgery were lower than that of US (all P < 0.01), except when the lesion size was >5 cm (P > 0.05).
US was better than MG in the preoperative evaluation of breast diseases of Chinese women. These results suggest that US could be more useful for detecting breast lesions in China, especially for younger women with dense breasts.
本研究旨在比较X线钼靶摄影（MG）和超声检查（US）在中国女性乳腺疾病诊断中的应用。
我们回顾性分析了2011年3月至2014年11月在安徽医科大学第二附属医院（中国合肥）诊断为乳腺疾病的274例患者的X线钼靶摄影以及超声检查结果和手术/病理结果。以手术病理检查结果作为金标准，将MG和US数据与手术记录进行比较。
MG检测乳腺癌的总体灵敏度、特异度、准确度、假阳性率、假阴性率、阳性预测值和阴性预测值分别为88.5%、57.9%、73.7%、42.1%、11.5%、69.2%和82.5%，而US分别为95.9%、66.7%、81.8%、33.3%、4.1%、75.5%和93.8%。在274例病例中，MG测量的病变大小与手术结果相符的有133例（48.5%），而US为216例（78.8%）（P<0.01）。MG确定的病变位置与手术结果相符的有146例（53.3%），而US为257例（93.8%）（P<0.01）。然后根据年龄、月经状态、乳腺密度和乳腺体积对这些数值进行分层，除病变大小>5 cm时（P>0.05），MG与手术结果的符合率低于US（所有P<0.01）。
在对中国女性乳腺疾病的术前评估中，US优于MG。这些结果表明，US在中国检测乳腺病变方面可能更有用，尤其是对于乳腺致密的年轻女性。
