一种与具有聚集诱导发光（AIE）特性的光敏剂共轭的铂前药，用于药物活化监测以及针对顺铂耐药癌细胞的联合光动力化疗。
A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic-chemotherapy against cisplatin resistant cancer cells.
作者信息
Yuan Youyong, Zhang Chong-Jing, Liu Bin
机构信息
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore117585.
出版信息
Chem Commun (Camb). 2015 May 21;51(41):8626-9. doi: 10.1039/c5cc01952d.
PMID:25898264
Abstract
A targeted and image-guided platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics was designed for real-time and in situ drug activation monitoring in cancer cells as well as combinational photodynamic-chemotherapy against cisplatin resistant cancer cells.
摘要
设计了一种与具有聚集诱导发光（AIE）特性的光敏剂共轭的靶向性图像引导铂前药，用于癌细胞中药物激活的实时原位监测以及对顺铂耐药癌细胞的光动力-化疗联合治疗。
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