Leonard Phoebe H, Hokenstad Alexis N, Khan Zaraq, Jensen Jani R, Stewart Elizabeth A, Coddington Charles C
J Reprod Med. 2015 Mar-Apr;60(3-4):103-8.
To evaluate pregnancy rates based on the route of progesterone replacement in frozen embryo transfer (FET) cycles.
A randomized controlled trial and retrospective analysis. In the randomized group 76 FET cycles were randomized. In the retrospective group 508 FET cycles were reviewed. Intramuscular (IM) proges-erone in oil 100 mg daily or oral micronized progesterone prior to transfer followed by compounded vaginal proges-erone 200 mg 3 times daily (OV). The main outcome measure was the clinical pregnancy rate (CPR).
Baseline characteristics did not vary be-ween groups in either cohort. In the randomized group there were no significant differences in CPR (31.43% vs. 21.05%) or live birth rate (LBR) (31.43% vs. 18.92%) for IM and OV progesterone replacement, respectively. In the retrospective cohort patients there wore also no significant differences in CPR (35.56% vs. 32.35%) or LBR (32.23% vs. 28.51%)f or the IM and OVp rogester-ne replacement groups, respectively.
This study demonstrates that either OV or IM progesterone is effective for luteal phase support for FETs.
评估冷冻胚胎移植（FET）周期中基于孕激素替代途径的妊娠率。
一项随机对照试验和回顾性分析。随机分组组中，76个FET周期被随机分组。回顾性分析组中，对508个FET周期进行了回顾。移植前每日肌内注射（IM）100mg油剂黄体酮，或口服微粒化黄体酮，随后每日3次经阴道给予复方黄体酮200mg（OV）。主要观察指标为临床妊娠率（CPR）。
两个队列中各组间的基线特征无差异。在随机分组组中，IM和OV途径替代黄体酮的CPR（分别为31.43%对21.05%）或活产率（LBR）（分别为31.43%对18.92%）无显著差异。在回顾性队列患者中，IM和OV途径替代黄体酮组的CPR（分别为35.56%对32.35%）或LBR（分别为32.23%对28.51%）也无显著差异。
本研究表明，OV或IM途径给予黄体酮对FET黄体期支持均有效。
