Toce S S, Farrell P M, Leavitt L A, Samuels D P, Edwards D K
Am J Dis Child. 1984 Jun;138(6):581-5. doi: 10.1001/archpedi.1984.02140440065017.
Because investigation of bronchopulmonary dysplasia (BPD) has been hampered by imprecise methods for diagnosis and grading of severity, we evaluated new clinical and roentgenographic scoring systems in neonates with severe respiratory distress. The study population included 110 premature neonates who were admitted consecutively over a two-year period and who required mechanical ventilation. The clinical scoring system used measures of gas exchange, respiratory distress, and growth rate; roentgenographic scoring involved numerical assessment of features characteristic of BPD. A significant correlation was noted at 21 days of age between clinical and roentgenographic scores. In a linear stepwise multiple regression, we found that the best predictors of clinical score were birth weight (ie, degree of prematurity) and roentgenographic score. With further development and validation, BPD scoring should be helpful by improving our understanding of the epidemiology of this disease, providing a means for evaluation of treatment, and facilitating multicenter investigations.
由于支气管肺发育不良（BPD）的诊断和严重程度分级方法不精确，阻碍了对其的研究，我们评估了用于患有严重呼吸窘迫的新生儿的新的临床和X线评分系统。研究人群包括在两年期间连续入院且需要机械通气的110例早产新生儿。临床评分系统使用气体交换、呼吸窘迫和生长速率的测量指标；X线评分涉及对BPD特征性表现的数值评估。在21日龄时，临床评分与X线评分之间存在显著相关性。在线性逐步多元回归分析中，我们发现临床评分的最佳预测因素是出生体重（即早产程度）和X线评分。随着进一步的发展和验证，BPD评分通过提高我们对该疾病流行病学的理解、提供治疗评估手段以及促进多中心研究，应该会有所帮助。
