Ryu Ki-Jin, Park Hyun-Tae, Kwon Dae Hui, Yang Kyung-Sook, Kim Yong Jin, Yi Kyong Wook, Shin Jung Ho, Hur Jun Young, Kim Tak
1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seongbuk-gu, Seoul, South Korea 2Department of Biostatistics, Korea University College of Medicine, Seongbuk-gu, Seoul, South Korea.
Menopause. 2015 Nov;22(11):1239-45. doi: 10.1097/GME.0000000000000461.
This study aims to evaluate the association between vasomotor symptoms and risk of metabolic syndrome in Korean postmenopausal women.
We carried out a cross-sectional study of 1,906 Korean postmenopausal women (aged 45-65 y) who were attending a routine health checkup at an institution in Korea from January 2010 to December 2012. To assess vasomotor symptoms, we created a dichotomous variable (none or present) using Menopause Rating Scale results. Metabolic syndrome was defined by the updated criteria of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III).
In total, 1,906 women were included in the analysis; 1,105 (58.0%) women reported some degree of vasomotor symptoms. Women with vasomotor symptoms were younger and had shorter duration of menopause, higher body mass index, larger waist circumference, more adverse lipid profile, and higher prevalence of metabolic syndrome compared with women without vasomotor symptoms. On multivariate analysis, vasomotor symptoms were associated with metabolic syndrome after adjusting for confounding factors, including age, body mass index, homeostasis model assessment of insulin resistance, duration of menopause, alcohol consumption, current smoking, and physical exercise level (odds ratio, 1.8; 95% CI, 1.3-2.4; P < 0.001).
The presence of vasomotor symptoms is associated with metabolic syndrome in Korean postmenopausal women. Lipid abnormalities and obesity seem to be important metabolic components associated with these symptoms. Vasomotor symptoms, if validated in longitudinal studies, may possibly serve as warning signs for identifying women at high risk for metabolic syndrome and cardiovascular disease.
本研究旨在评估韩国绝经后女性血管舒缩症状与代谢综合征风险之间的关联。
我们对2010年1月至2012年12月在韩国某机构进行常规健康检查的1906名韩国绝经后女性（年龄45 - 65岁）开展了一项横断面研究。为评估血管舒缩症状，我们根据更年期评分量表结果创建了一个二分变量（无或有）。代谢综合征采用美国国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家小组（成人治疗小组第三次报告）的更新标准进行定义。
总计1906名女性纳入分析；1105名（58.0%）女性报告有一定程度的血管舒缩症状。与无血管舒缩症状的女性相比，有血管舒缩症状的女性更年轻，绝经时间更短，体重指数更高，腰围更大，血脂谱更差，代谢综合征患病率更高。多变量分析显示，在调整包括年龄、体重指数、胰岛素抵抗稳态模型评估、绝经时间、饮酒、当前吸烟和体育锻炼水平等混杂因素后，血管舒缩症状与代谢综合征相关（比值比为1.8；95%置信区间为1.3 - 2.4；P<0.001）。
韩国绝经后女性血管舒缩症状的存在与代谢综合征相关。脂质异常和肥胖似乎是与这些症状相关的重要代谢成分。血管舒缩症状若在纵向研究中得到验证，可能会成为识别代谢综合征和心血管疾病高危女性的警示信号。
