Yang L, Xie Y, Li B, Xie M, Wang X, Zhang J
1 College of Electronic Engineering, Chengdu University of Information Technology, Chengdu, Sichuan, China.
Br J Radiol. 2015 Jun;88(1050):20150132. doi: 10.1259/bjr.20150132. Epub 2015 Apr 22.
To retrospectively assess the value of left and right half symmetry analysis in prostate T2 weighted images (T2WI) for improving prostate cancer (PCa) screening.
T2WI and other data of a total of 66 males were collected; the control group and cancer group had 33 patients each. Thresholding geometric active contours algorithm was used for prostate region segmentation, and the measure of local reflectional symmetry algorithm was applied to extract the longitudinal symmetry axes. After that, cross-correlation coefficients (CCs) of the left and right halves of each prostate were obtained.
Data analysis showed that the mean and variance of the value of the left and right half CCs of prostate T2WI in the cancer group and control group were 0.73 ± 0.05 and 0.82 ± 0.06, respectively. The area under the receiver operating characteristic curve was 0.87, and the specificity and the sensitivity were 91% and 70%, respectively. The p < 0.001 indicated that the value of CCs of the prostates between the two groups was significantly different.
The symmetry in T2WI is a potential useful index for PCa screening and has a potential value for PCa detection and localizations of tumours for biopsy.
Texture bilateral symmetry of prostate T2WI is employed to screen the suspected prostate tumour.
回顾性评估前列腺T2加权成像（T2WI）中左右半对称分析在改善前列腺癌（PCa）筛查方面的价值。
收集了66名男性的T2WI及其他数据；对照组和癌症组各有33例患者。采用阈值几何活动轮廓算法进行前列腺区域分割，并应用局部反射对称算法提取纵向对称轴。之后，获得每个前列腺左右半部分的互相关系数（CCs）。
数据分析表明，癌症组和对照组前列腺T2WI左右半部分CCs值的均值和方差分别为0.73±0.05和0.82±0.06。受试者工作特征曲线下面积为0.87，特异性和敏感性分别为91%和70%。p<0.001表明两组之间前列腺CCs值存在显著差异。
T2WI中的对称性是PCa筛查的一个潜在有用指标，对PCa检测以及肿瘤活检定位具有潜在价值。
利用前列腺T2WI的纹理双侧对称性来筛查可疑前列腺肿瘤。
