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Upregulation of miR-301a correlates with poor prognosis in triple-negative breast cancer.miR-301a的上调与三阴性乳腺癌的不良预后相关。
Med Oncol. 2014 Nov;31(11):283. doi: 10.1007/s12032-014-0283-2. Epub 2014 Oct 14.
2
A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease.miR-4513种子区域的一个基因变异对脂质和葡萄糖稳态、血压及冠状动脉疾病具有多效性影响。
Hum Mutat. 2014 Dec;35(12):1524-31. doi: 10.1002/humu.22706.
3
Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease.心血管生物学与疾病中的非编码RNA，包括微小RNA和长链非编码RNA
Cells. 2014 Aug 22;3(3):883-98. doi: 10.3390/cells3030883.
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Prognostic value of miR-221-3p, miR-342-3p and miR-491-5p expression in colon cancer.miR-221-3p、miR-342-3p 和 miR-491-5p 在结肠癌中的表达及其预后价值。
Am J Transl Res. 2014 Jul 18;6(4):391-401. eCollection 2014.
5
Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.中国人群中微小RNA多态性与心肌梗死风险的关联
Tohoku J Exp Med. 2014 Jun;233(2):89-94. doi: 10.1620/tjem.233.89.
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Association of miR-146a rs2910164 with childhood IgA nephropathy.miR-146a rs2910164与儿童IgA肾病的关联。
Pediatr Nephrol. 2014 Oct;29(10):1979-86. doi: 10.1007/s00467-014-2818-3. Epub 2014 Apr 30.
7
miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2.微小RNA-499通过对程序性细胞死亡蛋白4和多囊蛋白分选蛋白2的作用，保护心肌细胞免受过氧化氢诱导的凋亡。
RNA Biol. 2014;11(4):339-50. doi: 10.4161/rna.28300. Epub 2014 Feb 27.
8
microRNAs in cardiovascular diseases: current knowledge and the road ahead.微小 RNA 在心血管疾病中的作用：当前的认识和未来的方向。
J Am Coll Cardiol. 2014 Jun 3;63(21):2177-87. doi: 10.1016/j.jacc.2014.01.050. Epub 2014 Feb 26.
9
Prognostic role of microRNA polymorphisms in patients with advanced esophageal squamous cell carcinoma receiving platinum-based chemotherapy.miRNA 多态性对接受铂类化疗的晚期食管鳞癌患者预后的影响。
Cancer Chemother Pharmacol. 2014 Feb;73(2):335-41. doi: 10.1007/s00280-013-2364-x. Epub 2013 Nov 28.
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miRBase: annotating high confidence microRNAs using deep sequencing data.miRBase：利用深度测序数据注释高可信度 microRNAs。
Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73. doi: 10.1093/nar/gkt1181. Epub 2013 Nov 25.

miRNA 相关多态性对冠心病临床结局的影响。

Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease.

机构信息

Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.

出版信息

Am J Transl Res. 2015 Feb 15;7(2):393-400. eCollection 2015.

PMID:25901206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4399102/
Abstract

Genetic variants in pre-microRNA (miRNA) genes or the 3'UTR of miRNA target genes could influence miRNA-mediated regulation of gene expression and thus contribute to the susceptibility and prognosis of human diseases. This study aimed to investigate the effect of 6 miRNA-related polymorphisms (miR-149 rs71428439, miR-146a rs2910164, miR-499 rs3746444, miR-423 rs6505162, miR-4513 rs2168518, and FABP2 rs11724758) on prognosis in 1004 patients with angiographic coronary artery disease (CAD). We found that miR-4513 rs2168518 was associated with blood pressure, triglycerides, total cholesterol, and fasting glucose levels, and risk of diabetes mellitus. miR-499 rs3746444 and miR-423 rs6505162 were associated with blood pressure and HDL levels, respectively. Both miR-4513 rs2168518 and miR-499 rs3746444 had significant impact on even-free survival. Furthermore, miR-4513 rs2168518 was associated with higher morality in CAD patients. In conclusion, miR-4513 rs2168518 and miR-499 rs3746444 might be potential biomarkers for the clinical prognosis of CAD.

摘要

miRNA 基因前体（miRNA）或 miRNA 靶基因 3'UTR 中的遗传变异可能影响 miRNA 介导的基因表达调控，从而导致人类疾病的易感性和预后。本研究旨在探讨 6 个 miRNA 相关多态性（miR-149 rs71428439、miR-146a rs2910164、miR-499 rs3746444、miR-423 rs6505162、miR-4513 rs2168518 和 FABP2 rs11724758）对 1004 例经血管造影确诊的冠心病（CAD）患者预后的影响。我们发现 miR-4513 rs2168518 与血压、甘油三酯、总胆固醇和空腹血糖水平以及糖尿病风险相关。miR-499 rs3746444 和 miR-423 rs6505162 分别与血压和 HDL 水平相关。miR-4513 rs2168518 和 miR-499 rs3746444 对无事件生存均有显著影响。此外，miR-4513 rs2168518 与 CAD 患者的死亡率升高相关。总之，miR-4513 rs2168518 和 miR-499 rs3746444 可能是 CAD 临床预后的潜在生物标志物。