miRNA 相关多态性对冠心病临床结局的影响。
Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease.
机构信息
Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.
出版信息
Am J Transl Res. 2015 Feb 15;7(2):393-400. eCollection 2015.
Abstract
Genetic variants in pre-microRNA (miRNA) genes or the 3'UTR of miRNA target genes could influence miRNA-mediated regulation of gene expression and thus contribute to the susceptibility and prognosis of human diseases. This study aimed to investigate the effect of 6 miRNA-related polymorphisms (miR-149 rs71428439, miR-146a rs2910164, miR-499 rs3746444, miR-423 rs6505162, miR-4513 rs2168518, and FABP2 rs11724758) on prognosis in 1004 patients with angiographic coronary artery disease (CAD). We found that miR-4513 rs2168518 was associated with blood pressure, triglycerides, total cholesterol, and fasting glucose levels, and risk of diabetes mellitus. miR-499 rs3746444 and miR-423 rs6505162 were associated with blood pressure and HDL levels, respectively. Both miR-4513 rs2168518 and miR-499 rs3746444 had significant impact on even-free survival. Furthermore, miR-4513 rs2168518 was associated with higher morality in CAD patients. In conclusion, miR-4513 rs2168518 and miR-499 rs3746444 might be potential biomarkers for the clinical prognosis of CAD.
摘要
miRNA 基因前体（miRNA）或 miRNA 靶基因 3'UTR 中的遗传变异可能影响 miRNA 介导的基因表达调控，从而导致人类疾病的易感性和预后。本研究旨在探讨 6 个 miRNA 相关多态性（miR-149 rs71428439、miR-146a rs2910164、miR-499 rs3746444、miR-423 rs6505162、miR-4513 rs2168518 和 FABP2 rs11724758）对 1004 例经血管造影确诊的冠心病（CAD）患者预后的影响。我们发现 miR-4513 rs2168518 与血压、甘油三酯、总胆固醇和空腹血糖水平以及糖尿病风险相关。miR-499 rs3746444 和 miR-423 rs6505162 分别与血压和 HDL 水平相关。miR-4513 rs2168518 和 miR-499 rs3746444 对无事件生存均有显著影响。此外，miR-4513 rs2168518 与 CAD 患者的死亡率升高相关。总之，miR-4513 rs2168518 和 miR-499 rs3746444 可能是 CAD 临床预后的潜在生物标志物。
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