Associations of the rs2910164 and the rs3746444 Polymorphisms With Plasma Lipid Levels: A Meta-Analysis.

The studies of miRNAs are vibrant and remain at the forefront in the cardiovascular system. Emerging studies indicate that the genetic polymorphisms of the gene may affect lipid metabolism; this study aims to clarify the specific correlations between the rs2910164 and rs3746444 polymorphisms and lipid levels. A comprehensive search of literature was performed from December 31, 2020, to May 31, 2021, by searching of the PubMed and the Cochrane databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels between the genotypes. rs2910164, a functional polymorphism in the gene, was associated with increased triglycerides (TG) (SMD = 0.35, 95% CI = 0.15-0.54, < 0.001), total cholesterol (TC) (SMD = 0.43, 95% CI = 0.16-0.70, < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.37, 95% CI = 0.11-0.63, = 0.01) as well as decreased high-density lipoprotein cholesterol (HDL-C) (SMD = -0.27, 95% CI = -0.47-0.07, = 0.01) levels. rs3746444, a functional polymorphism in the gene, was only correlated with decreased TG (SMD = -0.09, 95% CI = -0.17-0.01, = 0.03) levels. The rs2910164 polymorphism is significantly associated with atherogenic dyslipidemia.