Liu Fuqiang, Wang Shengping, Luo Zhi
Department of Cardiology, First People's Hospital of Chengdu, Chengdu, China.
Department of Internal Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Front Genet. 2021 Sep 27;12:746686. doi: 10.3389/fgene.2021.746686. eCollection 2021.
The studies of miRNAs are vibrant and remain at the forefront in the cardiovascular system. Emerging studies indicate that the genetic polymorphisms of the gene may affect lipid metabolism; this study aims to clarify the specific correlations between the rs2910164 and rs3746444 polymorphisms and lipid levels. A comprehensive search of literature was performed from December 31, 2020, to May 31, 2021, by searching of the PubMed and the Cochrane databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels between the genotypes. rs2910164, a functional polymorphism in the gene, was associated with increased triglycerides (TG) (SMD = 0.35, 95% CI = 0.15-0.54, < 0.001), total cholesterol (TC) (SMD = 0.43, 95% CI = 0.16-0.70, < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.37, 95% CI = 0.11-0.63, = 0.01) as well as decreased high-density lipoprotein cholesterol (HDL-C) (SMD = -0.27, 95% CI = -0.47-0.07, = 0.01) levels. rs3746444, a functional polymorphism in the gene, was only correlated with decreased TG (SMD = -0.09, 95% CI = -0.17-0.01, = 0.03) levels. The rs2910164 polymorphism is significantly associated with atherogenic dyslipidemia.
对微小RNA（miRNAs）的研究充满活力，在心血管系统领域一直处于前沿。新出现的研究表明，该基因的遗传多态性可能影响脂质代谢；本研究旨在阐明rs2910164和rs3746444多态性与脂质水平之间的具体相关性。通过检索PubMed和Cochrane数据库，对2020年12月31日至2021年5月31日的文献进行了全面搜索。采用标准化均值差（SMD）和95%置信区间（CI）来评估不同基因型之间脂质水平的差异。rs2910164是该基因的一个功能性多态性位点，与甘油三酯（TG）升高（SMD = 0.35，95% CI = 0.15 - 0.54，P < 0.001）、总胆固醇（TC）升高（SMD = 0.43，95% CI = 0.16 - 0.70，P < 0.001）、低密度脂蛋白胆固醇（LDL - C）升高（SMD = 0.37，95% CI = 0.11 - 0.63，P = 0.01）以及高密度脂蛋白胆固醇（HDL - C）降低（SMD = -0.27，95% CI = -0.47 - 0.07，P = 0.01）水平相关。rs3746444是该基因的一个功能性多态性位点，仅与TG降低（SMD = -0.09，95% CI = -0.17 - 0.01，P = 0.03）水平相关。rs2910164多态性与致动脉粥样硬化性血脂异常显著相关。
