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对在肌醇-[³H]预先标记的鸟类红细胞中发现的肌醇-[³H]三磷酸酯的分析。

An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes.

作者信息

Stephens L R, Hawkins P T, Downes C P

机构信息

Smith Kline and French Research Limited, The Frythe, Welwyn, Herts., U.K.

出版信息

Biochem J. 1989 Sep 15;262(3):727-37. doi: 10.1042/bj2620727.

DOI:10.1042/bj2620727
PMID:2590163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1133335/
Abstract

Evidence is presented to show that acid extracts of avian erythrocytes prelabelled for 24-48 h with myo-[3H]inositol contain the following myo-[3H]inositol trisphosphates (expressed as a percentage of total myo-[3H]inositol trisphosphates extracted): 36% myo-[3H]inositol 1,4,5-trisphosphate; 33.7% myo-[3H]inositol 1,3,4-trisphosphate; 13% myo-[3H]inositol 3,4,5-trisphosphate; 9.7% myo-[3H]inositol 3,4,6-trisphosphate; 4.4% myo-[3H]inositol 1,4,6-trisphosphate and 3.3% myo-[3H]inositol 1,3,6-trisphosphate. The only phosphatidyl-myo-[3H]inositol bisphosphate that could be detected in [3H]Ins-prelabelled avian erythrocytes was phosphatidyl-myo-[3H]inositol 4,5-bisphosphate. Cellular myo-[3H]inositol 3,4,5-trisphosphate may be synthesized by dephosphorylation of myo-[3H]inositol 3,4,5,6-tetrakisphosphate. D- and L-myo-[3H]inositol 1,4,6-trisphosphate and D- and L-myo-[3H]inositol 1,3,6-trisphosphate may be dephosphorylation products of myo-[3H]inositol 1,3,4,6-tetrakisphosphate.

摘要

有证据表明，用肌醇-[3H]预标记24 - 48小时的禽红细胞酸性提取物含有以下肌醇-[3H]三磷酸（以提取的总肌醇-[3H]三磷酸的百分比表示）：36%的肌醇-[3H]1,4,5 - 三磷酸；33.7%的肌醇-[3H]1,3,4 - 三磷酸；13%的肌醇-[3H]3,4,5 - 三磷酸；9.7%的肌醇-[3H]3,4,6 - 三磷酸；4.4%的肌醇-[3H]1,4,6 - 三磷酸和3.3%的肌醇-[3H]1,3,6 - 三磷酸。在[3H]肌醇预标记的禽红细胞中能够检测到的唯一磷脂酰 - 肌醇-[3H]二磷酸是磷脂酰 - 肌醇4,5 - 二磷酸。细胞内的肌醇-[3H]3,4,5 - 三磷酸可能是由肌醇-[3H]3,4,5,6 - 四磷酸去磷酸化合成的。D - 和L - 肌醇-[3H]1,4,6 - 三磷酸以及D - 和L - 肌醇-[3H]1,3,6 - 三磷酸可能是肌醇-[3H]1,3,4,6 - 四磷酸的去磷酸化产物。

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A simple assay method for determination of the specific radioactivity of the gamma-phosphate group of 32P-labelled ATP.一种用于测定32P标记的ATP的γ-磷酸基团比放射性的简单测定方法。
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Inositol 1,2-cyclic 4,5-trisphosphate concentration relative to inositol 1,4,5-trisphosphate in pancreatic minilobules on stimulation with carbamylcholine in the absence of lithium. Possible role as a second messenger in long- but not short-term responses.在无锂情况下用氨甲酰胆碱刺激时，胰腺小叶中1,2-环肌醇4,5-三磷酸相对于肌醇1,4,5-三磷酸的浓度。在长期而非短期反应中作为第二信使的可能作用。
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